Larysa Voytenko
Karolinska InstituteStockholm, Sweden
330059 RESULTS
Karolinska InstituteStockholm, Sweden
CONFERENCE COVERAGE 2011-06-28 Conference Coverage Founded in 1477, Uppsala University in Sweden has a long tradition of advancing the cutting edge of medicine, from its pharmacopeiac gardens tended by Carl Linnaeus of taxonomy fame, to a seventeenth-century anatomy theater hosting pub
RESEARCH NEWS 2011-06-28 Research News The classic scientific method requires a hypothesis—but sometimes it can be refreshing to dive in without one. The authors of two screens, published this week, took just that approach and came up with pathological pathways linked to two diff
COMMENT These are interesting studies, and the conclusions drawn by the authors, though based on a relatively low "n" (nine-15 subjects per group) and a short duration of treatment (four weeks), provide food for thought. Numerous studies have shown (1)
PAPER Bulló M, Casas-Agustench P, Amigó-Correig P, Aranceta J, Salas-Salvadó J
COMMENT Unique clinical observations and elegant genetic research have established that approximately 10-12 percent of people with Parkinson’s have a mutation in one copy of a gene encoding the lysosomal enzyme glucocerebrosidase, or GBA1 (Sidransky et al., 2009)
COMMENT Mazzulli et al. describe an incredibly important study linking the activity of the lysosomal enzyme, glucocerebrosidase, with the accumulation and fibrilization of α-synuclein. Their study extends previous research into the correlation of glucocerebrosida
University of California, San DiegoSan Diego, United States
COMMENT This certainly is an impressive amount of work focusing thoroughly on the mechanistic link between glucocerebrosidase (GCase), glucocerebroside (GlcCer), and α-synuclein by robustly combining, in vitro, Gaucher's disease (GD), animal model, and human
University of OxfordOxford
COMMENT This paper by the Krainc group confirms previous work by our group and others, and provides a nice insight into the possible mechanisms by which dysregulation or mutation in the glucocerebrosidase (GBA) protein can lead to synucleinopathies. The cell work
PAPER Xu YH, Quinn B, Witte D, Grabowski GA
PAPER Sun Y, Quinn B, Witte DP, Grabowski GA
PAPER Spencer BJ, Verma IM
PAPER Crawford GD, Le WD, Smith RG, Xie WJ, Stefani E, Appel SH
No filters selected