PAPER Luo X, Prior M, He W, Hu X, Tang X, Shen W, Yadav S, Kiryu-Seo S, Miller R, Trapp BD, Yan R
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PAPER Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.
Sci Transl Med. 2011 May 25;3(84):84ra44. PubMed: 21613623PAPER Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, Scearce-Levie K, Wang W, Wu Y, Tessier-Lavigne M, Watts RJ
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo.
Sci Transl Med. 2011 May 25;3(84):84ra43. PubMed: 21613622Pieter Jelle Visser
Maastricht University; VU University Medical CentreMaastricht, Netherlands
Stephen Salloway
Brown UniversityProvidence, United States
Takeshi Iwatsubo on Smuggling Antibodies to BACE Across the Blood-Brain Barrier
COMMENT Reading the two excellent papers from Genentech, I was quite impressed by their elegant approach to raise anti-BACE1 antibodies that reduce Aβ production in vivo in brain. They further engineered the anti-BACE1 antibody by coupling it with a low-affinity
Ikram Ullah
Korea, Republic of
Hrishikesh Rangnekar
National AIDS Research InstitutePune, India
Smuggling Antibodies to BACE Across the Blood-Brain Barrier
RESEARCH NEWS 2011-05-27 Research News The tight barrier between brain and blood vessels guards the brain from harm, but it also frustrates scientists trying to deliver therapeutic molecules to the central nervous system (CNS). In the May 25 Science Translational Medicine, resear
Lysosomal Block Clogs Transport, Swells Neurites
RESEARCH NEWS 2011-05-27 Research News In the brains of people with Alzheimer’s disease, misshapen neurons clog with organelles—ironically, the very ones in the autophagic-lysosomal system that normally help cells dispose of damaged organelles and protein waste. This abnormality
PAPER Ming GL, Song H
Adult neurogenesis in the mammalian brain: significant answers and significant questions.
Neuron. 2011 May 26;70(4):687-702. PubMed: 21609825PAPER Grill JD, Ringman JM
Should persons with autosomal dominant AD be included in clinical trials?
Alzheimers Res Ther. 2011;3(3):18. PubMed: 21609419PAPER Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, Dejesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Woodruff BK, Knopman DS, White CL, Van Gerpen JA, Meschia JF, Mackenzie IR, Boylan K, Boeve BF, Miller BL, Strong MJ, Uitti RJ, Younkin SG, Graff-Radford NR, Petersen RC, Wszolek ZK, Dickson DW, Rademakers R
Ataxin-2 repeat-length variation and neurodegeneration.
Hum Mol Genet. 2011 Aug 15;20(16):3207-12. PubMed: 21610160PAPER Kolykhalov IV, Rassadina GA, Gavrilova SI, Gerasimov NP
Cholinergic treatment of Alzheimer's disease and its influence on health and the quality of life of carers.
Neurosci Behav Physiol. 2011 Jun;41(5):542-7. PubMed: 21611694PAPER Kinsley CH, Franssen RA, Meyer EA
Reproductive Experience may Positively Adjust the Trajectory of Senescence.
Curr Top Behav Neurosci. 2011 May 25; PubMed: 21611905Current Filters
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