PAPER La Joie R, Perrotin A, Barré L, Hommet C, Mézenge F, Ibazizene M, Camus V, Abbas A, Landeau B, Guilloteau D, De la Sayette V, Eustache F, Desgranges B, Chételat G
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330988 RESULTS
Kristel Sleegers on Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
COMMENT These studies provide further evidence that the genetic architecture of Alzheimer's disease does indeed include rare variants of intermediate penetrance, analogous to our work on rare variants in the GRN (Brouwers et al., 2008) and CLU genes (Bettens
Sylvain Lesne on Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.
COMMENT This new report from Kaj Blennow and Oskar Hansson's group appears to support our own findings that soluble α-synuclein levels are increased in brains of subjects with AD (Larson et al., 2012). Whether this elevation corresponds to a "leakage of
David Sulzer on Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.
COMMENT The line of mice introduced in this study indicates what happens when macroautophagy is specifically blocked in dopamine (DA) neurons by deletion of Atg7, a key component of the autophagy machinery. There have been, to my knowledge, three such floxed Atg7
Kristel Sleegers
University of AntwerpAntwerpen, Belgium
PAPER Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.
J Neurochem. 2008 Jul;106(1):24-36. PubMed: 18384642PAPER Lazarou M, Jin SM, Kane LA, Youle RJ
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.
Dev Cell. 2012 Feb 14;22(2):320-33. PubMed: 22280891PAPER Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM