331007 RESULTS
COMMENT The finding of a decrease in the AICD 49-99/50-99 ratio due to APP mutations near the γ- or ε-site is intriguing, and may partly answer why these mutations increase the Aβ 42/40 ratio if the step-wise cleavage hypothesis is correct. That GSMs have no effe
United States
COMMENT This is a fascinating report that seems to help clarify the roles of inflammation-related immune agents in AD. There has been some confusion and controversy arising from the findings that innate immune reactions appear to contribute to the development of
COMMENT The study by Das et al. was meticulously conducted and provides an important platform for further work in understanding how Aβ production normally occurs. It has been known for some time that Aβ secretion is activity-dependent, but the precise mechanisms
PAPER Ducruet AF, Zacharia BE, Sosunov SA, Gigante PR, Yeh ML, Gorski JW, Otten ML, Hwang RY, DeRosa PA, Hickman ZL, Sergot P, Connolly ES
MUTATIONS PSEN1 73659438 GRCh37/hg19 C A g.44654C> A g.61260C> A Exon 7 Point, Missense Coding Aβ42/Aβ40 ratio increased and Aβ37/Aβ42 ratio decreased in cultured cells. Neuropathology consistent with AD in two carriers, including neurofibrillary tangles (Bra
Coimbatore, India
RESEARCH NEWS 2013-08-15 Research News Memories come with a hefty price tag. When energy is plentiful, neurons expend a lot of it to make new memory proteins at synapses; alas, under stress, neurons cut back on that protein synthesis to conserve resources. Could that impair memor
PAPER Kanaan NM, Manfredsson FP
PAPER Rothman SM, Griffioen KJ, Vranis N, Ladenheim B, Cong WN, Cadet JL, Haran J, Martin B, Mattson MP
PAPER Kurowska Z, Englund E, Widner H, Lindvall O, Li JY, Brundin P
PAPER Cersosimo MG, Raina GB, Calandra CR, Pellene A, Gutiérrez C, Micheli FE, Benarroch EE
PAPER Magen I, Chesselet MF
PAPER Huang Y, Rowe DB, Halliday GM
PAPER Kim WS, Halliday GM
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