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C9ORF72 Throws a Wrench into DNA Repair Machinery

RESEARCH NEWS 2017-07-21 Research News Hexanucleotide expansions in the C9ORF72 gene—the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia—mount a multipronged attack on the DNA repair system, according to a July 17 study in Nature ...

PAPER Frisoni GB, Boccardi M, Barkhof F, Blennow K, Cappa S, Chiotis K, Démonet JF, Garibotto V, Giannakopoulos P, Gietl A, Hansson O, Herholz K, Jack CR Jr, Nobili F, Nordberg A, Snyder HM, Ten Kate M, Varrone A, Albanese E, Becker S, Bossuyt P, Carrillo MC, Cerami C, Dubois B, Gallo V, Giacobini E, Gold G, Hurst S, Lönneborg A, Lovblad KO, Mattsson N, Molinuevo JL, Monsch AU, Mosimann U, Padovani A, Picco A, Porteri C, Ratib O, Saint-Aubert L, Scerri C, Scheltens P, Schott JM, Sonni I, Teipel S, Vineis P, Visser PJ, Yasui Y, Winblad B

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers.

Lancet Neurol. 2017 Aug;16(8):661-676. Epub 2017 Jul 11 PubMed: 28721928

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