Steven Brenner on Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)

COMMENT I think the locus ceruleus is definitely implicated in Alzheimer’s disease, perhaps in some way mediating synaptic plasticity, which is an early casualty in the Alzheimer’s disease war on the brain. I had treated a number of mice and rats in the early 198

Steven Brenner on San Diego: ALS Research Goes to the Dogs

COMMENT The dog models do probably have a lot of advantages over mice, especially since they seem to be endogenous models rather than induced through genetic manipulation. Another large animal model that seems to be largely overlooked is equine motor neuron disea

PAPER Divers TJ, Cummings JE, de Lahunta A, Hintz HF, Mohammed HO

Evaluation of the risk of motor neuron disease in horses fed a diet low in vitamin E and high in copper and iron.

Am J Vet Res. 2006 Jan;67(1):120-6. PubMed: 16426221

PAPER Han F, Shioda N, Moriguchi S, Yamamoto Y, Raie AY, Yamaguchi Y, Hino M, Fukunaga K

Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus.

J Pharmacol Exp Ther. 2008 Jul;326(1):127-34. PubMed: 18388258

PAPER Shioda N, Yamamoto Y, Han F, Moriguchi S, Yamaguchi Y, Hino M, Fukunaga K

A novel cognitive enhancer, ZSET1446/ST101, promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice.

J Pharmacol Exp Ther. 2010 Apr;333(1):43-50. PubMed: 20068029

Bob Modan

Princeton, United States

Homer

ANTIBODY polyclonal manufacturer Cat# ab88827<br />Reference: <br /><a href="/papers/dendritic-function-tau-mediates-amyloid-beta-toxicity-alzheimers-disease-mouse-models" target="_new">Ittner, 2010</a> immunogen = full

PAPER Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

Am J Pathol. 2010 Jul;177(1):311-24. PubMed: 20522652

Src, phosY529

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Src, phosY418

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GLUT1

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San Diego: ApoE, Aβ, and AD—Strengthening the Synaptic Connection

CONFERENCE COVERAGE 2010-12-07 Conference Coverage Amyloid-β plaque load poorly associates with cognition in Alzheimer’s disease (AD) and in people with mild cognitive impairment. Synapse loss, on the other hand, is believed to be a major correlate of cognitive decline. At this year’s

San Diego: Subcortical Blues—Locus Ceruleus in AD, Neurodegeneration

CONFERENCE COVERAGE 2010-12-07 Conference Coverage Though it could well be the subcortical brain region hit hardest in Alzheimer’s and Parkinson’s, the blue spot, or locus ceruleus, has only recently begun to draw wider attention among neurodegeneration scientists. New work presented a

Ira Singer

NOVA Health Care Group
Herndon, United States

PAPER Micheva KD, Busse B, Weiler NC, O'Rourke N, Smith SJ

Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers.

Neuron. 2010 Nov 18;68(4):639-53. PubMed: 21092855