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Tau V337M

RESEARCH MODELS Modification Details Human 4-repeat tau driven by the PDGF-β promoter. Tagged with myc and Flag on the N- and C-terminals respectively. Neuropathology SDS-insoluble tau aggregates in hippocampus. Degenerating neurons in the hippocampus containing phosphor

Tau R406W transgenic

RESEARCH MODELS Modification Details Transgene containing human 4-repeat tau cDNA with the R406W mutation containing myc and FLAG tags at N-and C-terminal ends, respectively, and driven by the CaMK-II promoter. Neuropathology Argyrophilic and congophilic tau inclusions i

hBACE

RESEARCH MODELS Summary Three lines of transgenic mice expressing different levels of human BACE were generated. Line 30 (BACE-L) expressed the lowest amount of BACE, followed by line 34 (BACE-M), and line 8 (BACE-H). These lines expressed human BACE at levels approximat

Turning to the Internet for Alzheimer’s Trial Volunteers

CONFERENCE COVERAGE 2013-11-27 Conference Coverage Slow enrollment often hobbles Alzheimer’s clinical trials. At a November 1–2 meeting at the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, stakeholders brainstormed ways to reach new participants and keep them engaged.

Do Tau Tracers Track Cognitive Decline in Disease?

CONFERENCE COVERAGE 2013-11-27 Conference Coverage Pathology studies show that tau tangles, unlike amyloid, track closely with the cognitive decline of Alzheimer’s disease. This has raised hope that the tau PET tracers being developed will allow researchers to stage disease, and early

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