PAPER Ridge PG, Ebbert MT, Kauwe JS
SEARCH RESULTS
330026 RESULTS
PAPER Jagust W
Biomarkers and Brain Connectivity.
JAMA Neurol. 2013 Aug 19; PubMed: 23959142PAPER Zhang SH, Reddick RL, Piedrahita JA, Maeda N
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E.
Science. 1992 Oct 16;258(5081):468-71. PubMed: 1411543APOE Knock-out
RESEARCH MODELS Modification Details Inactivation of the endogenous mouse APOE by homologous recombination and insertion of a neomycin cassette. Other Phenotypes ApoE is undetectable in the plasma of these homozygous APOE knock-out mice. They are viable and appear health
APOE2 Targeted Replacement
RESEARCH MODELS Summary Targeted gene replacement was used to replace the endogenous murine APOE gene with the human APOE2 allele. In humans, the APOE2 allele is associated with decreased risk of Alzheimer's disease and an increased risk for type III hyperlipoprotei
APOE3 Targeted Replacement
RESEARCH MODELS Summary Gene targeting was used to replace the endogenouse murine APOE gene with the human APOE3 allele. On a standard diet, homozygous mice have normal cholesterol and triglyceride levels, but are more susceptible than wild-type animals to diet-induced a
APOE4 Targeted Replacement
RESEARCH MODELS Summary Gene targeting was used to replace the endogenous murine APOE gene with the human APOE4 allele. The mice are at increased risk of atherosclerosis compared with wild-type animals or mice expressing human APOE3. On a standard chow diet the mice have