330986 RESULTS
COMMENT The concept of "strains" emanates from the prion field. It has been shown both in vitro and in animal models that the disease-associated prion protein (PrPsc) can exhibit differences in misfolding and aggregation. These different forms tend to b
MUTATIONS APP 27264132 GRCh37/hg19 rs63750921 C G g.275305C> G g.284001C> G Exon 17 Point, Missense Coding Accelerated nucleation of Aβ aggregates in vitro Severe CAA; Hemorrhages originating from affected vessels; “Vessel-within-vessel” morphology; Absence o
MUTATIONS APP 27269905 GRCh37/hg19 G A g.278679G> A g.278228G> A Exon 16 Point, Missense Coding Significantly increased total Aβ and Aβ42/Aβ40 levels; Shifts BACE1 cleavage toward the β-site. May also accelerate aggregation. Bilateral hippocampal volume loss;
RESEARCH NEWS 2013-07-09 Research News In the brains of people with Parkinson’s disease and dementia, both tau and α-synuclein often co-aggregate. This is no case of two independent inclusions forming side-by-side, but of one seeding the other, suggests a paper in the July 3 Cell
PAPER Yan J, Fu X, Ge F, Zhang B, Yao J, Zhang H, Qian J, Tomozawa H, Naiki H, Sawashita J, Mori M, Higuchi K
COMMENT This study by LaClair et al. is one of several studies coordinated by Sangram Sisodia. First and foremost, the principal conclusion, highlighted in the title, is that bexarotene did not improve cognition. However, the data clearly demonstrate that the aut
PAPER Wu L, Tian YY, Shi JP, Xie W, Shi JQ, Lu J, Zhang YD
PAPER Wang C, Feng X, Xie S, Gu Z, Chan P
PAPER Hong X, Zhang ZX, Wu LY, Shi LL, Zhao XH, Wei J
PAPER Rodríguez JJ, Noristani HN, Hilditch T, Olabarria M, Yeh CY, Witton J, Verkhratsky A
PAPER Sesele K, Thanopoulou K, Paouri E, Tsefou E, Klinakis A, Georgopoulos S
PAPER Park H, Yang JJ, Seo J, Lee JM,
PAPER Fehér Á, Juhász A, László A, Pákáski M, Kálmán J, Janka Z
PAPER Huang L, Jia J, Liu R
PAPER Ibáñez C, Simó C, Barupal DK, Fiehn O, Kivipelto M, Cedazo-Mínguez A, Cifuentes A
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