RESEARCH NEWS 2010-10-20 Research News The Parkinson’s Progression Markers Initiative (PPMI) was launched in July with hopes of identifying a biomarker, or set of markers, that tracks the natural course of Parkinson disease in 400 newly diagnosed PD patients and 200 healthy contr

PAPER Cookson MR

Pathways to Parkinsonism.

Neuron. 2003 Jan 9;37(1):7-10. PubMed: 12526767

PPMI: Parkinson's Field’s Answer to ADNI

RESEARCH NEWS 2010-10-19 Research News One of the great challenges with developing treatments for neurodegenerative disorders stems from the capricious nature of disease progression, where symptoms remain hidden or unchanged for years, perhaps even decades, despite steady accumul

Amyloid β pE3 (2G6)

ANTIBODY monoclonal 2G6 manufacturer Cat# ABM-102A-100 immunogen = (3-8) N-terminal pyroglutamated synthetic amyloid beta peptide conjigated with a carrier protein liquid, ascites, azide free reactive to N-terminal truncated Ab starting with pyroglutamate (pGlu, p

Thomas Willnow on Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.

COMMENT The study by Vieira and colleagues investigates a potential role for APP phosphorylation in regulation of retrograde transport from endosomes to the trans-Golgi network (TGN). Recently, this trafficking route received particular attention because of the a

Lennart Mucke on Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

COMMENT By demonstrating a selective vulnerability of hilar interneurons to intracellularly generated neurotoxic ApoE4 fragments, Andrews-Zwilling et al. identified an interesting new mechanism through which ApoE4 could contribute to neural network dysfunction in

PAPER Borroni B, Bonvicini C, Galimberti D, Tremolizzo L, Papetti A, Archetti S, Turla M, Alberici A, Agosti C, Premi E, Appollonio I, Rainero I, Ferrarese C, Gennarelli M, Scarpini E, Padovani A

Founder effect and estimation of the age of the Progranulin Thr272fs mutation in 14 Italian pedigrees with frontotemporal lobar degeneration.

Neurobiol Aging. 2011 Mar;32(3):555.e1-8. PubMed: 20947212

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Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier.

Rapid and direct detection of apolipoprotein E genotypes using whole blood from humans.

Assessment of the RBANS Visual and Verbal Indices in a sample of neurologically impaired elderly participants.

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

Incidence and predictors of eating disability among nursing home residents with middle-stage dementia.

Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain.

High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease.

Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale).

PPMI: Brain Imaging To Reveal Preclinical Parkinson’s Signature?