PDAPP(line109)

RESEARCH MODELS Summary The PDAPP mouse was first described in 1995 (Games et al., 1995) and is considered one of the earliest mouse models of Alzheimer's disease. From a young age this model exhibits cognitive deficits in a variety of tasks, including spatial worki

Lawrence Wennogle

Intra-Cellular Therapies, Inc.
New York, United States

Dongze Xi

China

jean-philippe courade

Discoveric bio alpha
Geneva, Switzerland

Amelia Stevens

United States

KIM JOHNSON

TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER
LUBBOCK, United States

APPSwDI x NOS2 Knock-out

RESEARCH MODELS Neuropathology Abundant plaques, especially in the thalamus and subiculum. Aggregated, hyperphosphorylated tau tangles. Neuronal loss, especially of neuropeptide Y (NPY) neurons in the hippocampus and subiculum. Compared to Tg-SwDI mice, the bigenic mice

Eduardo R. Zimmer

Federal University of Rio Grande do Sul
Brazil

jef Tritch

United States

Schwen Larson

�
United States

Eric Hamlett

Medical University of South Carolina (MUSC)
Charleston, United States

Tau Tracers Shine at Boston Conference

CONFERENCE COVERAGE 2013-08-11 Conference Coverage Ligands that light up tau on brain scans generated plenty of buzz among researchers attending the Alzheimer's Association International Conference, held July 13-18 in Boston. Presenters at the meeting offered the latest data on th

PAPER Coelho-Cerqueira E, Carmo-Gonçalves P, Pinheiro AS, Cortines J, Follmer C

α-Synuclein as an intrinsically disordered monomer - fact or artefact?

FEBS J. 2013 Oct;280(19):4915-27. PubMed: 23927048

PAPER Bedi SS, Walker PA, Shah SK, Jimenez F, Thomas CP, Smith P, Hetz RA, Xue H, Pati S, Dash PK, Cox CS

Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury.

J Trauma Acute Care Surg. 2013 Sep;75(3):410-6. PubMed: 23928737

PAPER Tovar KR, McGinley MJ, Westbrook GL

Triheteromeric NMDA receptors at hippocampal synapses.

J Neurosci. 2013 May 22;33(21):9150-60. PubMed: 23699525