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APP

ALZPEDIA The amyloid precursor protein (APP) is central to the study of Alzheimer’s disease. Abundant in neurons, APP is a type I transmembrane protein whose proteolysis gives rise to amyloid-β (Aβ) peptides. Rare mutations in APP cause familial Alzheimer’s diseas

Can Dousing PyroGlu-Aβ Treat Alzheimer’s Disease?

CONFERENCE COVERAGE 2013-03-20 Conference Coverage Read a PDF of the entire series. Pyroglutamate Aβ is a particularly toxic version of the peptide at the center of Alzheimer’s disease pathogenesis; in fact, some scientists claim it seeds the formation of plaques (for a review, see Gun

How Cognitive Stimulation Might Protect Against Aβ Oligomers

WEBINAR 2013-03-20 Cognitive stimulation has been shown to lower the risk of Alzheimer’s disease, but what actually happens in the brain to confer protection? In the March 6 Neuron, researchers led by Dennis Selkoe report that β2-adrenergic signaling plays a key role. Wild-

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