171147 RESULTS

At High Doses, BACE1 Inhibitors Hinder Synaptic Plasticity in Mice

RESEARCH NEWS 2014-11-28 Research News The goal of BACE1 inhibition is to stop the production of toxic Aβ. However, a new study reports that at very high doses, the inhibitors may harm the very neurons they are meant to protect. Initial findings were presented by senior author ...

Multiple Mutations Hasten ALS Onset, Suggests Genetic Study

RESEARCH NEWS 2014-11-27 Research News The genomes of people with amyotrophic lateral sclerosis, even so-called sporadic cases, are often blemished by rare variants that may increase risk for the disease. Some unlucky folk tote two or even three of these potential risk alleles, ...

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