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Design From Disorder: New Test Reveals Different Strains of SOD1

RESEARCH NEWS 2015-03-27 Research News When individual proteins form aggregates, they shed the shapes they once took as lone monomers for others that fit in with the collective. A new technique capitalizes on this often-disorderly transition to detect different strains of ...

Emily Reedich, C.J. Heckman, Katharina Quinlan on Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.

COMMENT Cortical abnormalities in hSOD1 G93A mouse model confirm a key role of synaptic dysfunction in ALS Amyotrophic lateral sclerosis (ALS) is characterized by the concomitant dysfunction of corticospinal motoneurons (CSMNs) in the primary motor cortex, and ...

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