CONFERENCE COVERAGE 2016-12-07 Add Private note Add An editorial note Conference Coverage Many researchers now believe that misfolded proteins spread from cell to cell across the brain, corrupting normal proteins as they go, yet exactly how this propagation would happen remains unclear ...
WEBINAR 2016-12-07 Add Private note Add An editorial note Humans are not alone in accumulating Aβ in their brain. Squirrel monkeys, vervets, lemurs, apes, other nonhuman primates, and even dogs develop copious amyloid plaques and cerebral amyloid angiopathy as they age. ...
PAPER Gerdes HH, Rustom A, Wang X23246917
PAPER Hollister JR, Lee KS, Dorward DW, Baron GS
Efficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brain.PLoS One. 2015;10(1):e0115351. Epub 2015 Jan 30 PubMed: 25635871
CPNSS LSELondon, United Kingdom
UNC CharlotteCharlotte, United States
COMMENT In this work, Iaccarino et al. find that specific manipulation of brain gamma activity rapidly over an hour lowers Aβ40 and 42 levels as well as affects microglial gene expression in such a way as to make them more phagocytic. Over time, increasing gamma ...
COMMENT This study is an ingenious attempt to determine whether interventions that stimulate fast neuronal oscillations in the brain can ameliorate Alzheimer’s pathology. The study contains four key findings: 40 Hz optogenetic stimulation of parvalbumin-positive ...
RESEARCH NEWS 2016-12-07 Add Private note Add An editorial note Research News Could staring into a strobe light prevent or treat Alzheimer’s disease? A paper in the December 8 Nature hints as much. Scientists led by Li-Huei Tsai and Edward Boyden from MIT used both optogenetics ...
PAPER Aron L, Yankner BA
PAPER Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH
Inserm U1077Caen, France
Ventura CountyNewbury Park, United States
U PennPhiladelphia, United States
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