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New Role for PINK1 Offers Clues about Parkinson's Pathology

RESEARCH NEWS 2014-03-28 Research News Researchers have zeroed in on a mechanism that may promote the earliest stages of mitochondrial decline in Parkinson’s disease (PD). Mutations that hinder the kinase activity of the mitochondria-associated protein PINK1 trigger the derailmen

Researchers Build on GWAS to Parse Genetic Players in AD and PD

CONFERENCE COVERAGE 2014-03-28 Conference Coverage The train of discovery powered by genome-wide association studies (GWAS) is losing steam, so researchers are turning to a different experimental fuel to drive progress on the genetics of Alzheimer's and Parkinson's diseases.

PAPER Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stefánsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.

Hum Mol Genet. 2012 Nov 15;21(22):4996-5009. Epub 2012 Aug 13 PubMed: 22892372

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