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Alzheimer’s Risk Genes Interact in Immune Cells

RESEARCH NEWS 2015-10-02 Research News Do Alzheimer’s risk genes act as lone wolves, or do they run as a pack? A paper in the 28 September Nature Neuroscience suggests the latter. Researchers led by Philip De Jager and Elizabeth Bradshaw at Brigham and Women’s Hospital, Boston, ...

Jeremy Garson on Do Sleeper Viruses Awaken in ALS?

COMMENT Several prior strands of evidence (mainly indirect) pointed to the possibility of retroviral involvement in ALS. These can be summarized as follows: Since the 1980s, certain murine retroviruses have been known to cause a motor-neuron disease in mice. The ...

Do Sleeper Viruses Awaken in ALS?

RESEARCH NEWS 2015-10-02 Research News A hibernating retrovirus, prodded from slumber, can provoke neurodegeneration, according to a paper in the September 30 Science Translational Medicine. Human endogenous retrovirus-K pumps out viral RNA and proteins in a subset of amyotrophic ...

PAPER Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

Nature. 2011 Mar 17;471(7338):325-30. Epub 2011 Feb 6 PubMed: 21297615

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