PAPER Araujo NB, Barca ML, Engedal K, Coutinho ES, Deslandes AC, Laks J
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PAPER Dalkara T, Gursoy-Ozdemir Y, Yemisci M
Brain microvascular pericytes in health and disease.
Acta Neuropathol. 2011 Jul;122(1):1-9. PubMed: 21656168PAPER Sood PK, Nahar U, Nehru B
Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain.
Neurotox Res. 2011 Nov;20(4):351-61. PubMed: 21656326PAPER Akinleye I, Roberts JS, Royal CD, Linnenbringer E, Obisesan TO, Fasaye GA, Green RC
Differences between African American and White research volunteers in their attitudes, beliefs and knowledge regarding genetic testing for Alzheimer's disease.
J Genet Couns. 2011 Dec;20(6):650-9. PubMed: 21656311PAPER Wang D, Yang L, Su J, Niu Y, Lei X, Xiong J, Cao X, Hu Y, Mei B, Hu JF
Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin 1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline.
Biochem Biophys Res Commun. 2011 Jul 1;410(2):229-34. PubMed: 21651893PAPER Saijo E, Scheff SW, Telling GC
Unaltered prion protein expression in Alzheimer disease patients.
Prion. 2011 Apr-Jun;5(2):109-16. PubMed: 21654203PAPER Malpass K
MRI may predict the onset of Alzheimer disease.
Nat Rev Neurol. 2011 Jun;7(6):302. PubMed: 21654711Jadie Anderson
United States
John Breitner on Feeding Frenzy—Therapeutics Tap Tryptophan, Cathepsins, HDACs, Zinc
COMMENT The primary outcome data from the reaZin study appear to be consistent with the proposed action of the intervention. The three cognitive and functional measures used for the series of secondary outcomes are appropriate, but the small size of the sample me
M. Flint Beal on Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
COMMENT This is an interesting study that examined the neuroprotective efficacy of JM6, a small molecule inhibitor of kynurenine 3-monooxygenase (KMO). The authors demonstrate that oral administration of JM6 inhibits KMO in the blood, resulting in an increase in
Penny Hallett on Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
COMMENT In the Cell paper by Zwilling et al. on oral kynurenine 3-monooxygenase (KMO) inhibition in Huntington's and Alzheimer's transgenic mouse models, a striking effect was the prevention of pre-synaptic protein loss in the transgenic models of AD (A
Marianna Siapera
Aristotle University of ThessalonikiGreece
Li Gan on The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.
COMMENT Aβ-lowering effects of E64d are very intriguing. However, since E64d inhibits numerous cathepsins, the mechanism by which E64d lowers Aβ remains unclear. Moreover, given the recent finding from Randy Nixon's group that inhibitors of cathepsins, inclu
PAPER Barrett AJ, Kembhavi AA, Brown MA, Kirschke H, Knight CG, Tamai M, Hanada K
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.
Biochem J. 1982 Jan 1;201(1):189-98. PubMed: 7044372Jack de la Torre
University of Texas at AustinAustin, United States
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