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william petrie
Vanderbilt medical centernashville, United States
PAPER Douaud G, Refsum H, de Jager CA, Bradley K, Jacoby RS, Smith AD
Disease-modification in MCI with homocysteine-lowering B vitamins slows atrophy of particular brain regions: the VITACOG trial
J Nutr Health Aging. 2011;15:S12.David Holtzman on Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.
COMMENT A major limitation of antibodies and other therapeutic proteins is that when given peripherally, the amount that gets across the BBB is only a small fraction of the concentration in the blood. One receptor that is normally involved in transporting a molec
bill ihlenfeldt
CVTCeau claire, United States
Hans de Swart
EnVivo International BVLeiden, Netherlands
PAPER Nogalska A, D'Agostino C, Engel WK, Askanas V
Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis.
Neurobiol Dis. 2014 May;65:93-101. Epub 2014 Jan 25 PubMed: 24472798PAPER Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS
Increased Ndfip1 in the substantia nigra of parkinsonian brains is associated with elevated iron levels.
PLoS One. 2014;9(1):e87119. Epub 2014 Jan 24 PubMed: 24475238PAPER Neupane K, Solanki A, Sosova I, Belov M, Woodside MT
Diverse metastable structures formed by small oligomers of α-synuclein probed by force spectroscopy.
PLoS One. 2014;9(1):e86495. Epub 2014 Jan 24 PubMed: 24475132PAPER Gould N, Mor DE, Lightfoot R, Malkus K, Giasson B, Ischiropoulos H
Evidence of native α-synuclein conformers in the human brain.
J Biol Chem. 2014 Mar 14;289(11):7929-34. Epub 2014 Jan 28 PubMed: 24474688PAPER Scarlata S, Golebiewska U
Linking alpha-synuclein properties with oxidation: a hypothesis on a mechanism underling cellular aggregation.
J Bioenerg Biomembr. 2014 Apr;46(2):93-8. Epub 2014 Jan 29 PubMed: 24474217PAPER Jellinger KA
The pathomechanisms underlying Parkinson's disease.
Expert Rev Neurother. 2014 Feb;14(2):199-215. PubMed: 24471711PAPER Bayatti N, Cooper-Knock J, Bury JJ, Wyles M, Heath PR, Kirby J, Shaw PJ
Comparison of blood RNA extraction methods used for gene expression profiling in amyotrophic lateral sclerosis.
PLoS One. 2014;9(1):e87508. Epub 2014 Jan 27 PubMed: 24475299PAPER Menon P, Kiernan MC, Vucic S
Cortical dysfunction underlies the development of the split-hand in amyotrophic lateral sclerosis.
PLoS One. 2014;9(1):e87124. Epub 2014 Jan 24 PubMed: 24475241PAPER Bruijn L, Cudkowicz M, ALS Clinical Trials Working Group
Opportunities for improving therapy development in ALS.
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):169-73. Epub 2014 Jan 29 PubMed: 24472060Current Filters
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