PAPER Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S, Lakshmana MK
SEARCH RESULTS
330883 RESULTS
PAPER Goldsworthy MR, Vallence AM
The Role of β-Amyloid in Alzheimer's Disease-Related Neurodegeneration.
J Neurosci. 2013 Aug 7;33(32):12910-1. PubMed: 23926246PAPER Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P
Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions.
J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. PubMed: 23926248PAPER Zhu Z, Yan J, Jiang W, Yao XG, Chen J, Chen L, Li C, Hu L, Jiang H, Shen X
Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance.
J Neurosci. 2013 Aug 7;33(32):13138-49. PubMed: 23926267AA HH on Researchers Join to Draw Posterior Cortical Atrophy Out of Shadows
COMMENT My mother is 10 years into this disease. I knew she was sick when she couldn't plug the telephone cord into the wall. She also had difficulty aiming the metal part into the base when putting her seat belt on. Neurologists said they couldn't find
Gerri Stevens on Pooled GWAS Reveals New Alzheimer’s Genes and Pathways
COMMENT As a facilitator for the Alzheimer's support group in Trinidad, Colorado, and with three family members who had Alzheimer's disease, I am always interested in any new research information. At my current age of 73, I am at the same age that my th
Florence Clavaguera, Markus Tolnay, Michel Goedert on Are Protein Strains The Cause of Different Tauopathies?
COMMENT This report raises the question whether strains made of four tau repeats are related to pathological tau aggregates found in human brain. The question is answered in the affirmative, because seeds prepared from different human tauopathies gave rise to tau
3xTg
RESEARCH MODELS Summary These widely-used mice contain three mutations associated with familial Alzheimer's disease (APP Swedish, MAPT P301L, and PSEN1 M146V). The mice are viable, fertile, and display no initial gross physical or behavioral abnormalities. Translati
Lawrence Rajendran on Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.
COMMENT This is a spectacular study, linking lipid metabolism, membrane trafficking and Alzheimer's disease. It is carefully done, combining elegant cell biology in neurons with biochemistry. For me, the most important aspect of the study is that the finding
Peter Ham
Mansfield, United States
5xFAD (B6SJL)
RESEARCH MODELS Summary 5xFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1. Three lines were generated ori
PSEN1 L286V
MUTATIONS PSEN1 73664825 GRCh37/hg19 rs63751235 C G g.50041C> G g.66647C> G Exon 8 Point, Missense Coding Increased Aβ42/Aβ total ratio, unchanged Aβ42/Aβ40 ratio, and increased Aβ43, Aβ42, and Aβ40 levels, with decreased non-amylodiogenic processing of APP i
Gerri Stevens
United States
More Evidence that γ-Secretase Modulators Spare Essential Substrates
RESEARCH NEWS 2013-08-09 Research News With recent trial failures dashing hopes for treating Alzheimer’s with γ-secretase inhibitors (see ARF news story and ARF news story), scientists are redoubling efforts to develop compounds that tweak this enzyme’s activity rather than stymi
Neural Activity Tips Endosomal Balance, Hastens Amyloid Pathology
RESEARCH NEWS 2013-08-09 Research News Aβ production depends on the rendezvous between the amyloid precursor protein (APP) and β-secretase (BACE-1). Two new studies explore the dynamics of this encounter. Scientists led by Subhojit Roy, University of California, San Diego, report
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