PAPER Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, Laferla FM, Kiyohara Y, Nakabeppu Y

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study.

Cereb Cortex. 2013 Apr 17; PubMed: 23595620

PAPER Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Wood A, Pangalos MN, Reinhart PH, Chin J

Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.

J Neurosci. 2013 Apr 17;33(16):7020-6. PubMed: 23595759

PAPER Liu B, Frost JL, Sun J, Fu H, Grimes S, Blackburn P, Lemere CA

MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.

J Neurosci. 2013 Apr 17;33(16):7027-37. PubMed: 23595760

PAPER Galimberti D, Scarpini E

Progress in Alzheimer's disease research in the last year.

J Neurol. 2013 Jul;260(7):1936-41. PubMed: 23595792

PAPER Goo JS, Kim YB, Shim SB, Jee SW, Lee SH, Kim JE, Hwang IS, Lee YJ, Kwak MH, Lim CJ, Hong JT, Hwang DY

Nicastrin Overexpression in Transgenic Mice Induces Aberrant Behavior and APP Processing.

Mol Neurobiol. 2013 Apr 18; PubMed: 23595812

PAPER Qiu C, von Strauss E, Bäckman L, Winblad B, Fratiglioni L

Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden.

Neurology. 2013 May 14;80(20):1888-94. PubMed: 23596063

PAPER

Exercise slows decline in adults with Alzheimer's disease.

Front Aging Neurosci. 2013;5:17. PubMed: 23596226

PAPER Diniz BS, Machado-Vieira R, Forlenza OV

Lithium and neuroprotection: translational evidence and implications for the treatment of neuropsychiatric disorders.

Neuropsychiatr Dis Treat. 2013;9:493-500. PubMed: 23596350

PAPER Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S

Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.

J Neurosci. 2013 Apr 17;33(16):7099-107. PubMed: 23595767

PAPER Harris JM, Gall C, Thompson JC, Richardson AM, Neary D, Du Plessis D, Pal P, Mann DM, Snowden JS, Jones M

Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia.

Neurology. 2013 May 14;80(20):1881-7. PubMed: 23596080

PAPER Jellinger KA

Pathology and pathogenesis of vascular cognitive impairment-a critical update.

Front Aging Neurosci. 2013;5:17. PubMed: 23596414

PAPER Geerts H, Roberts P, Spiros A, Carr R

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease.

Front Pharmacol. 2013;4:47. PubMed: 23596419

Rebecca M. Pruss on Stem Cell Screen Points to ALS Disease Target

COMMENT This is an exciting paper showing the ability to use a specific class of stem cell-derived neurons—motor neurons—to screen for potential neuroprotective small molecules. While the mouse ESC-derived neural cultures appear suitable for systematic screening,

Rebecca M. Pruss

TROPHOS
Marseille, France

PAPER Rubin LL

Stem cells and drug discovery: the beginning of a new era?

Cell. 2008 Feb 22;132(4):549-52. PubMed: 18295572