Parvathi Rudrabhatla
Research fellowBethesda, United States
331159 RESULTS
Research fellowBethesda, United States
COMMENT This is very interesting. I am wondering how to relate those findings to the roles of folate in brain function and cognitive aging in humans. Folate provides one carbon group to methylate DNA and other substrates. In population-based studies, low folate h
PAPER Feng L
PAPER Feng L, Ng TP, Chuah L, Niti M, Kua EH
COMMENT This comment by Stephen Strittmatter is based on two critical publications which I highly recommend reading (Talbot et al., 2012; Bomfim et al., 2012). 0 rbrinton Demonstrated brain insulin resistance in Alzheimer's disease patients is associated wit
COMMENT New APP Mutation Does Not Advance the Amyloid Hypothesis Debate In response to the question, Does β amyloid accumulation drive Alzheimer’s disease?, the answer is “most likely no,” and the new data presented by Jonsson et al. does not change that answer.
COMMENT I agree with the comments underlying the importance of this paper, which supports the pathogenic role of APP processing by BACE in sporadic AD. As noted in many comments, these findings also suggest that inhibition of BACE processing of APP will be a bene
Institute for Research in BiomedicineBarcelona, Spain
CONFERENCE COVERAGE 2012-07-18 Conference Coverage In Alzheimer’s disease drug development, how often does it happen that a large phase 2b trial of an experimental medicine cleanly meets both primary and secondary endpoints as set out in the protocol? Today, at the Alzheimer’s Associat
PAPER Premi E, Garibotto V, Alberici A, Paghera B, Giubbini R, Padovani A, Borroni B
PAPER Knight LS, Wenzel HJ, Schwartzkroin PA
PAPER Yang M, Kim JS, Kim J, Jang S, Kim SH, Kim JC, Shin T, Wang H, Moon C
PAPER Constant JP, Fraley GS, Forbes E, Hallas BH, Leheste JR, Torres G
PAPER Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D
PAPER Lang L, Kurnik M, Danielsson J, Oliveberg M
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