AβPP

ANTIBODY polyclonal manufacturer Cat# LS-C42820<br />manufacturer: LifeSpan Biosciences immunogen = synthetic peptide corresp. to aa737-751of human APP (C-terminal) recognizes both intact APP, and also the C99 fragment generated by Beta-secretase. The seq. r

AβPP

ANTIBODY polyclonal manufacturer Cat# LS-C42821<br />manufacturer: LifeSpan Biosciences immunogen = synthetic peptide corresp. to aa653-662 of human APP or 1-10 of the β-amyloid peptide (N-terminal) recognizes both intact APP and the 4kD β-amyloid peptide th

AβPP

ANTIBODY polyclonal manufacturer Cat# LS-C3639<br />manufacturer: LifeSpan Biosciences immunogen = synthetic peptide derived from the extreme C-terminus of human amyloid A4 protein precursor AβPP IgG APP, APLP, AICD Autogen Bioclear Rabbit Human Mouse Rat A&

NSE

ANTIBODY polyclonal manufacturer Cat# 16625<br />Reference: <br /><a href="/papers/distinct-region-specific-alpha-synuclein-oligomers-a53t-transgenic-mice-implications" target="_new">Tsika, 2010</a> lyophilized stains NS

PAPER Busquet P, Hetzenauer A, Sinnegger-Brauns MJ, Striessnig J, Singewald N

Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear.

Learn Mem. 2008 May;15(5):378-86. PubMed: 18441296

Tyrosine Hydroxylase (6D7)

ANTIBODY monoclonal 6D7 manufacturer Cat# 657010<br />Reference: <br /><a href="/papers/distinct-region-specific-alpha-synuclein-oligomers-a53t-transgenic-mice-implications" target="_new">Tsika, 2010</a> immunogen = tyro

PAPER Striessnig J, Koschak A, Sinnegger-Brauns MJ, Hetzenauer A, Nguyen NK, Busquet P, Pelster G, Singewald N

Role of voltage-gated L-type Ca2+ channel isoforms for brain function.

Biochem Soc Trans. 2006 Nov;34(Pt 5):903-9. PubMed: 17052224

PAPER Langwieser N, Christel CJ, Kleppisch T, Hofmann F, Wotjak CT, Moosmang S

Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels.

J Neurosci. 2010 Jun 23;30(25):8367-75. PubMed: 20573883

PAPER Chodosh J, Mittman BS, Connor KI, Vassar SD, Lee ML, DeMonte RW, Ganiats TG, Heikoff LE, Rubenstein LZ, Della Penna RD, Vickrey BG

Caring for patients with dementia: how good is the quality of care? Results from three health systems.

J Am Geriatr Soc. 2007 Aug;55(8):1260-8. PubMed: 17661967

krishna kanth

madras university
chennai, India

Bethesda: The Methylated Brain

CONFERENCE COVERAGE 2010-06-25 Conference Coverage One of the best-studied epigenetic modifications, methylation is the addition of a methyl group to a cytosine residue of DNA, usually at a cytosine paired to a guanine (CpG site). Methylation of gene promoters usually silences gene exp

Open and Shut Case: Calcium Channels in Axon Regeneration and Memory

RESEARCH NEWS 2010-06-25 Research News Voltage-gated calcium channels swing open with passing action potentials, allowing calcium ions into the cell, and slide shut when the membrane depolarization has passed. Two papers this month suggest that these channels—particularly the lon

Research Brief: Specific Care Plan Does Little for AD Patients

RESEARCH NEWS 2010-06-25 Research News For conditions as complex and devastating as Alzheimer disease, one might assume that guideline-based care delivered by multidisciplinary experts with skilled caregiver help would make some difference for patients. However, a study published

Research Brief: Presenilin Simplicity—Evidence for Autoproteolysis

RESEARCH NEWS 2010-06-25 Research News William of Occam contended that the simplest explanation is usually the best. Occam’s razor, as the maxim is now known, may not cut it every time, but as applied to γ-secretase—the proteolytic complex that slices and dices amyloid precursor

PAPER Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G

Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.

Biochemistry. 2010 Aug 3;49(30):6358-64. PubMed: 20568734