PAPER Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head R, Macaulay SL, Pertile K, Rowe CC, Rembach A, Rodrigues M, Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ames D, Masters CL, Martins RN,

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease.

Arch Neurol. 2012 Jul 16;:1-8. PubMed: 22801742

PAPER Wagner SL, Tanzi RE, Mobley WC, Galasko D

Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease.

Arch Neurol. 2012 Jul 16;:1-4. PubMed: 22801784

PAPER Wood H

Alzheimer disease: Prostaglandin E(2) signalling is implicated in inflammation early in the Alzheimer disease course.

Nat Rev Neurol. 2012 Aug;8(8):411. PubMed: 22801972

PAPER Warren JD, Fletcher PD, Golden HL

The paradox of syndromic diversity in Alzheimer disease.

Nat Rev Neurol. 2012 Aug;8(8):451-64. PubMed: 22801974

PAPER Santa-Maria I, Haggiagi A, Liu X, Wasserscheid J, Nelson PT, Dewar K, Clark LN, Crary JF

The MAPT H1 haplotype is associated with tangle-predominant dementia.

Acta Neuropathol. 2012 Jul 17; PubMed: 22802095

PAPER Opara JA

Activities of daily living and quality of life in Alzheimer disease.

J Med Life. 2012 Jun 12;5(2):162-7. PubMed: 22802883

Vítor Pinto

ICVS/3B’s - PT Government Associate Laboratory
Braga, Portugal

Pradeep Reddy Raamana

University of Pittsburgh
United States

Jens Pahnke on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT This is a nice finding by Jonsson et al., and adds more evidence to the idea published in 2009 by an Italian group that changes to this amino acid position in APP can prevent or facilitate aggregation of human Aβ. It seems that amino acids at position 2 o

Parvathi Rudrabhatla

Research fellow
Bethesda, United States

Lei Feng on A Boost for Waning DNA Tags Fixes Age-Related Memory Loss in Mice

COMMENT This is very interesting. I am wondering how to relate those findings to the roles of folate in brain function and cognitive aging in humans. Folate provides one carbon group to methylate DNA and other substrates. In population-based studies, low folate h

PAPER Feng L

Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline.

Am J Clin Nutr. 2012 May;95(5):1289-90; author reply 1290. PubMed: 22523150

PAPER Feng L, Ng TP, Chuah L, Niti M, Kua EH

Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study.

Am J Clin Nutr. 2006 Dec;84(6):1506-12. PubMed: 17158436

Roberta Diaz Brinton on Alzheimer’s disease: the new promise.

COMMENT This comment by Stephen Strittmatter is based on two critical publications which I highly recommend reading (Talbot et al., 2012; Bomfim et al., 2012). 0 rbrinton Demonstrated brain insulin resistance in Alzheimer's disease patients is associated wit

Matthew Zabel on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT New APP Mutation Does Not Advance the Amyloid Hypothesis Debate In response to the question, Does β amyloid accumulation drive Alzheimer’s disease?, the answer is “most likely no,” and the new data presented by Jonsson et al. does not change that answer.