PAPER Memedi M, Khan T, Grenholm P, Nyholm D, Westin J
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330029 RESULTS
PAPER Mast N, Li Y, Linger M, Clark M, Wiseman J, Pikuleva IA
Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.
J Biol Chem. 2014 Feb 7;289(6):3529-38. Epub 2013 Dec 18 PubMed: 24352658Maya Mitalipova
Whitehead Institute for Biomedical ResearchCambridge, United States
Richard Ransohoff on Beyond Neighborhood Watch—Microglia Nurture Synapses
COMMENT This paper reports a groundbreaking piece of work. The major new conceptual insight is that microglia play critical roles (as do all brain cells) in the development and maintenance of the CNS. One can no longer think of “resting” microglia because they’re
PAPER Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T
Layer V cortical neurons require microglial support for survival during postnatal development.
Nat Neurosci. 2013 May;16(5):543-51. Epub 2013 Mar 24 PubMed: 23525041Beyond Neighborhood Watch—Microglia Nurture Synapses
RESEARCH NEWS 2013-12-20 Research News Besides patrolling the brain for tissue damage and other emergencies, microglia also help with routine maintenance, according to new research in the December 19 Cell. In adult mice engineered to lose microglia on demand, Wenbiao Gan, New Yor
PAPER Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszewski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.
Nat Neurosci. 2013 Nov;16(11):1618-26. Epub 2013 Sep 29 PubMed: 24077561PAPER Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.
Nature. 2005 Dec 15;438(7070):1017-21. PubMed: 16355225Concepcion Goldberg, Terry Goldberg on Averting a Late-life Crisis: Midlife ApoE2 Clears Plaques in Mice
COMMENT We read with interest Hudry and Hyman's comprehensive set of studies examining the effects of ApoE2 and E4 isoforms in transgenic mice. Our own recent work, now in press at Molecular Psychiatry and all in humans (ex vivo and in vivo), nicely compleme
Concepcion Goldberg
The Feinstein Institute for Medical ResearchManhasset, United States
Carlos Cruchaga on Effect of TMEM106B Polymorphism on Functional Network Connectivity in Asymptomatic GRN Mutation Carriers.
COMMENT In this paper, Premi et al. describe the effect of the TMEM106B risk variant on functional connectivity in progranulin gene (GRN) mutation carriers, more specifically among asymptomatic carriers. This study provides very valuable information about the ear
Risk Genes Influence Brain Connectivity in Preclinical FTD
RESEARCH NEWS 2013-12-20 Research News Previous studies indicated that polymorphisms in the TMEM106B gene exacerbate frontotemporal dementia caused by progranulin mutations, advancing disease onset by more than a decade. Now, new research strengthens the case for that synergy, an
PAPER Borroni B, Alberici A, Cercignani M, Premi E, Serra L, Cerini C, Cosseddu M, Pettenati C, Turla M, Archetti S, Gasparotti R, Caltagirone C, Padovani A, Bozzali M
Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD.
Neurobiol Aging. 2012 Oct;33(10):2506-20. Epub 2011 Nov 29 PubMed: 22130207Premature Aging Protein Speeds Disease in Patient-Derived Neurons
RESEARCH NEWS 2013-12-20 Research News Age is the strongest environmental risk factor for Alzheimer’s, Parkinson’s, and other neurodegenerative disorders, and scientists often wish they could control the process when studying various disease models. Now they may get their wish. I
Michel Simonneau
INSERM U894Paris
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