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ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.

Hum Mol Genet. 2013 Jul 1;22(13):2676-88. Epub 2013 Mar 7 PubMed: 23474818

Jonas Neher on Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.

COMMENT This impressive study from Cornelius Gross’ group again highlights the importance of appropriate immune surveillance during brain development. They show that an insufficient number of microglia in the developing CNS results in synaptic pruning deficits an

PAPER Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F, Vyssotski AL, Bifone A, Gozzi A, Ragozzino D, Gross CT

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.

Nat Neurosci. 2014 Mar;17(3):400-6. Epub 2014 Feb 2 PubMed: 24487234

PAPER Neher JJ, Emmrich JV, Fricker M, Mander PK, Théry C, Brown GC

Phagocytosis executes delayed neuronal death after focal brain ischemia.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):E4098-107. Epub 2013 Oct 7 PubMed: 24101459

SORLA Serves Up Aβ for Destruction

RESEARCH NEWS 2014-02-14 Research News The giant metal claw at a junkyard carries pieces of metal off to be crushed. Could SORLA  dispose of Aβ in a similar way? In the February 12 Science Translational Medicine, scientists led by Thomas Willnow, Max-Delbrück-Center for Molecular

PAPER Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Füchtbauer EM, Füchtbauer A, Holtzman DM, Takagi J, Willnow TE

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

Sci Transl Med. 2014 Feb 12;6(223):223ra20. PubMed: 24523320

Jonas Neher

German Center for Neurodegenerative Diseases (DZNE)
Tuebingen , Germany

Tomas Falzone

CONICET
Duenos Aires, Argentina

Brendan Innes

Massachusetts General Hospital
Boston, United States

PAPER Kappeler L, De Magalhaes Filho C, Dupont J, Leneuve P, Cervera P, Périn L, Loudes C, Blaise A, Klein R, Epelbaum J, Le Bouc Y, Holzenberger M

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism.

PLoS Biol. 2008 Oct 28;6(10):e254. PubMed: 18959478

PAPER Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, Cervera P, Le Bouc Y

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.

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PAPER Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

J Biol Chem. 2014 Mar 21;289(12):8067-85. Epub 2014 Feb 11 PubMed: 24519935

PAPER Gjerde KV, Tysnes OB

[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].

Tidsskr Nor Laegeforen. 2014 Feb 11;134(3):302-6. PubMed: 24518478

PAPER Chen JM, Chang CW, Chang TH, Hsu CC, Horng JT, Sheu WH

Effects of statins on incident dementia in patients with type 2 DM: a population-based retrospective cohort study in Taiwan.

PLoS One. 2014;9(2):e88434. Epub 2014 Feb 10 PubMed: 24520388

PAPER Qiu WQ, Wallack M, Dean M, Liebson E, Mwamburi M, Zhu H

Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele.

PLoS One. 2014;9(2):e88063. Epub 2014 Feb 10 PubMed: 24520345