PAPER Bousquet M, Gibrat C, Ouellet M, Rouillard C, Calon F, Cicchetti F
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PAPER Antonini A, Bondiolotti G, Natuzzi F, Bareggi SR
Levodopa and 3-OMD levels in Parkinson patients treated with Duodopa.
Eur Neuropsychopharmacol. 2010 Oct;20(10):683-7. PubMed: 20570113PAPER Ducharme N, Banks WA, Morley JE, Robinson SM, Niehoff ML, Mattern C, Farr SA
Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration.
Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. PubMed: 20570588PAPER Meulenbroek O, Rijpkema M, Kessels RP, Rikkert MG, Fernández G
Autobiographical memory retrieval in patients with Alzheimer's disease.
Neuroimage. 2010 Oct 15;53(1):331-40. PubMed: 20570740PAPER Rodríguez-Rodríguez E, Vázquez-Higuera JL, Sánchez-Juan P, Mateo I, Pozueta A, Martínez-García A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O
Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.
J Alzheimers Dis. 2010;21(2):619-25. PubMed: 20571217PAPER Li RC, Guo SZ, Lee SK, Gozal D
Neuroglobin protects neurons against oxidative stress in global ischemia.
J Cereb Blood Flow Metab. 2010 Nov;30(11):1874-82. PubMed: 20571522PAPER Mielke MM, Lyketsos CG
Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
Neuromolecular Med. 2010 Dec;12(4):331-40. PubMed: 20571935Benjamin Wolozin on Law and Disorder—APPswe Patent Suits Raise Ruckus Again
COMMENT The report by Esther Landhuis and Gabrielle Strobel reflects the inherent intellectual and financial turbulence that evolves when advancing technology interfaces with the patent system and commercial system. First, let’s examine the patent issues. It is c
PAPER Pidsley R, Dempster EL, Mill J
Brain weight in males is correlated with DNA methylation at IGF2.
Mol Psychiatry. 2010 Sep;15(9):880-1. PubMed: 20010889PAPER Tycko B
Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS.
Am J Hum Genet. 2010 Feb 12;86(2):109-12. PubMed: 20159108PAPER Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty VV, Schupf N, Vilain E, Morris M, Haghighi F, Tycko B
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.
Nat Genet. 2008 Jul;40(7):904-8. PubMed: 18568024PAPER Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR
Human DNA methylomes at base resolution show widespread epigenomic differences.
Nature. 2009 Nov 19;462(7271):315-22. PubMed: 19829295Martin Forde on The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.
COMMENT Catalano et al. hypothesize that disruption of fibrils could result in an increase of soluble Aβ oligomers. I want to test this hypothesis in vivo, specifically that disrupting fibrils leads to increases in ADDLs that correlates with cognitive deficits in
Ralph Nixon on Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
COMMENT Reply to comment by Tony Wyss-Coray Since its very early descriptions, autophagy has been defined as the lysosomal digestion of a cell’s own cytoplasmic material and not simply the sequestration of these components. Implied by this definition, and general
Ana Maria Cuervo
Albert Einstein College of MedicineBronx, United States
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