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Small Brain Bleeds Lead To Bigger Problems in Alzheimer’s

RESEARCH NEWS 2015-03-28 Research News Tiny brain bleeds in Alzheimer’s patients put them at a higher risk of stroke and cardiovascular disease. Which one develops depends on where those microbleeds occur, according to the latest findings from the MISTRAL Study. Scientists led by ...

Design From Disorder: New Test Reveals Different Strains of SOD1

RESEARCH NEWS 2015-03-27 Research News When individual proteins form aggregates, they shed the shapes they once took as lone monomers for others that fit in with the collective. A new technique capitalizes on this often-disorderly transition to detect different strains of ...

Emily Reedich, C.J. Heckman, Katharina Quinlan on Motor Cortex Layer V Pyramidal Neurons Exhibit Dendritic Regression, Spine Loss, and Increased Synaptic Excitation in the Presymptomatic hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.

COMMENT Cortical abnormalities in hSOD1 G93A mouse model confirm a key role of synaptic dysfunction in ALS Amyotrophic lateral sclerosis (ALS) is characterized by the concomitant dysfunction of corticospinal motoneurons (CSMNs) in the primary motor cortex, and ...

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