PAPER Sayad A, Noruzinia M, Zamani M, Harirchian MH, Kazemnejad A

Association study of cathepsin d gene polymorphism in Iranian patients with sporadic late-onset Alzheimer's disease.

Dement Geriatr Cogn Disord. 2014;37(5-6):257-64. Epub 2013 Nov 23 PubMed: 24281128

PAPER Paterson RW, Toombs J, Slattery CF, Schott JM, Zetterberg H

Biomarker modelling of early molecular changes in Alzheimer's disease.

Mol Diagn Ther. 2014 Apr;18(2):213-27. PubMed: 24281842

PAPER Fernández G, Mandolesi P, Rotstein NP, Colombo O, Agamennoni O, Politi LE

Eye movement alterations during reading in patients with early Alzheimer disease.

Invest Ophthalmol Vis Sci. 2013 Dec 30;54(13):8345-52. PubMed: 24282223

PAPER Xu J, Wang H, Ding K, Lu X, Li T, Wang J, Wang C, Wang J

Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice.

Mediators Inflamm. 2013;2013:187873. Epub 2013 Oct 24 PubMed: 24282339

PAPER Krauss S, Vorberg I

Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins.

Int J Cell Biol. 2013;2013:704546. Epub 2013 Oct 26 PubMed: 24282413

PAPER Meeuwsen E, Melis R, van der Aa G, Golüke-Willemse G, de Leest B, van Raak F, Schölzel-Dorenbos C, Verheijen D, Verhey F, Visser M, Wolfs C, Adang E, Olde Rikkert M

Cost-effectiveness of one year dementia follow-up care by memory clinics or general practitioners: economic evaluation of a randomised controlled trial.

PLoS One. 2013;8(11):e79797. Epub 2013 Nov 25 PubMed: 24282511

PAPER Moran MT, Tare M, Kango-Singh M, Singh A

Homeotic Gene teashirt (tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration.

PLoS One. 2013;8(11):e80829. Epub 2013 Nov 25 PubMed: 24282556

PAPER Kapaki E, Paraskevas GP, Emmanouilidou E, Vekrellis K

The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.

PLoS One. 2013;8(11):e81654. Epub 2013 Nov 25 PubMed: 24282614

Steven Paul

Voyager Therapeutics
Cambridge , United States

Durgesh Tiwari

Monash University
Melbourne, Australia

PS1 P264L

RESEARCH MODELS Summary The PS1 P264L knock-in mouse line was derived using a two-step mutagenesis strategy similar to that used to generate the TgAPPSwe-KI line (Reaume et al., 1996). An advantage to this model is the mutant PSEN1 is expressed at normal levels and under

Helen Rochford

Sweden

TgAPPSwe-KI

RESEARCH MODELS Summary This model was generated using a gene-targeting strategy designed to enhance the production of human Aβ in the mouse brain without changing APP synthesis. Site-specific mutations were introduced into exon 16 of the mouse APP gene to humanize the A

hBACE54

RESEARCH MODELS Summary These mice were generated to determine how BACE overexpression affects the processing of APP in vivo. Two transgenic lines were reported (BACE54/4 and BACE54/11) both expressing human BACE at high levels in the brain. Human BACE mRNA was approxima

Maiken Nedergaard

University of Rochester Medical Center
United States