Tiernan O'Malley

Biogen
Cambridge, United States

PAPER Maret S, Faraguna U, Nelson AB, Cirelli C, Tononi G

Sleep and waking modulate spine turnover in the adolescent mouse cortex.

Nat Neurosci. 2011 Nov;14(11):1418-20. PubMed: 21983682

PAPER Bushey D, Tononi G, Cirelli C

Sleep and synaptic homeostasis: structural evidence in Drosophila.

Science. 2011 Jun 24;332(6037):1576-81. PubMed: 21700878

PAPER Tortorella C, Ruggieri M, Di Monte E, Ceci E, Iaffaldano P, Direnzo V, Mastrapasqua M, Frigeri A, Amato MP, Hakiki B, Ghezzi A, Lugaresi A, De Luca G, Patti F, D'amico E, Sola P, Simone AM, Svelto M, Livrea P, Trojano M

Serum and CSF N-acetyl aspartate levels differ in multiple sclerosis and neuromyelitis optica.

J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1355-9. PubMed: 21622936

PAPER Tsai GC, Stauch-Slusher B, Sim L, Hedreen JC, Rothstein JD, Kuncl R, Coyle JT

Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS.

Brain Res. 1991 Aug 9;556(1):151-6. PubMed: 1682006

PAPER Simone IL, Ruggieri M, Tortelli R, Ceci E, D'Errico E, Leo A, Zoccolella S, Mastrapasqua M, Capozzo R, Livrea P, Logroscino G

Serum N-acetylaspartate level in amyotrophic lateral sclerosis.

Arch Neurol. 2011 Oct;68(10):1308-12. PubMed: 21987545

June Kaplow

Eisai Inc.
Woodcliff Lake, United States

Gabor G. Kovacs

University of Toronto
Toronto, Canada

Andreas Müller-Schiffmann

Heinrich-Heine-University Düsseldorf
Düsseldorf, Germany

Aβ Antibody Gantenerumab Clears Plaques

RESEARCH NEWS 2011-10-14 Research News Another antibody joins the ranks of those reported to clear Aβ from the brains of patients with mild to moderate Alzheimer's disease. Gantenerumab, a human monoclonal antibody, clears plaques in a matter of months, report scientists at

Australia Report: The Way Forward—Pre-symptomatic Trials

CONFERENCE COVERAGE 2011-10-14 Conference Coverage Over the past five years, the field at large has reached strong consensus that clinical trials should treat people earlier. This should start with defined populations whose genotype, age, and/or biomarker status unquestionably put them

Amino Acid Clocks ALS Progression?

RESEARCH NEWS 2011-10-14 Research News Amyotrophic lateral sclerosis (ALS) has joined the growing list of neurodegenerative diseases characterized by fluctuations in the amino acid N-acetylaspartate (NAA)—but with a twist. While the amino acid is known to drop in the brains of pe

Sleep Trims Synaptic Spines in Adolescents

RESEARCH NEWS 2011-10-14 Research News Here is one more reason teenagers need their zzz's—it appears sleep is prime time for synapse remodeling in adolescence. Researchers led by Giulio Tononi from the University of Wisconsin, Madison, have shown for the first time that in a

PAPER Agosta F, Scola E, Canu E, Marcone A, Magnani G, Sarro L, Copetti M, Caso F, Cerami C, Comi G, Cappa SF, Falini A, Filippi M

White Matter Damage in Frontotemporal Lobar Degeneration Spectrum.

Cereb Cortex. 2011 Oct 10; PubMed: 21988828

Clearing the Fog Around Aβ Oligomers

WEBINAR 2011-10-14 Like calling a spade a spade? What about an Aβ oligomer? The study of this peptide’s oligomers has taken off in the last decade. Many labs have developed their own favorite means of making, purifying, and studying them. Researchers have isolated dimers, t