Tara Spires-Jones on Monomeric Aβ’s Disappearing Act in AD Brain: Two Theories

COMMENT These are two very interesting papers discussing the production of Aβ with age. Soyon Hong and Dennis Selkoe's work in awake, behaving mice is particularly interesting as it elegantly shows that dense plaques are in equilibrium with soluble Aβ in the

PAPER Gatz M, Mortimer JA, Fratiglioni L, Johansson B, Berg S, Reynolds CA, Pedersen NL

Potentially modifiable risk factors for dementia in identical twins.

Alzheimers Dement. 2006 Apr;2(2):110-7. PubMed: 19595867

PAPER Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A

Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.

N Engl J Med. 1986 Nov 13;315(20):1241-5. PubMed: 2430180

Ghafour Ghafari

United States

Whence and Where To: History and Future of AD Therapy Trials

CONFERENCE COVERAGE 2011-11-17 Conference Coverage Paul Aisen heads the Alzheimer's Disease Cooperative Study (ADCS), a federally funded clinical trials consortium headquartered at the University of California, San Diego. The ADCS hosted the 4th International Conference on Clinica

PAPER Perez DL, Larvie M, Acar D, Daffner K

Teaching NeuroImages: apathetic variant of frontotemporal dementia.

Neurology. 2011 Nov 15;77(20):e117. PubMed: 22084280

PAPER Homma T, Mochizuki Y, Mizutani T

Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe.

Neuropathology. 2011 Nov 14; PubMed: 22082318

PAPER Swarup V, Phaneuf D, Dupré N, Petri S, Strong M, Kriz J, Julien JP

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.

J Exp Med. 2011 Nov 21;208(12):2429-47. PubMed: 22084410

PAPER Sindreu C, Storm DR

Modulation of neuronal signal transduction and memory formation by synaptic zinc.

Front Behav Neurosci. 2011;5:68. PubMed: 22084630

PAPER Martin LJ

Mitochondrial pathobiology in ALS.

J Bioenerg Biomembr. 2011 Dec;43(6):569-79. PubMed: 22083126

PAPER Dzieciatkowska M, Qi G, You J, Bemis KG, Sahm H, Lederman HM, Crawford TO, Gelbert LM, Rothblum-Oviatt C, Wang M

Proteomic Characterization of Cerebrospinal Fluid from Ataxia-Telangiectasia (A-T) Patients Using a LC/MS-Based Label-Free Protein Quantification Technology.

Int J Proteomics. 2011;2011:578903. PubMed: 22084690

PAPER Ninan I

Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex.

J Neurochem. 2011 Oct;119(2):324-31. PubMed: 21848811

PAPER Rao-Ruiz P, Rotaru DC, van der Loo RJ, Mansvelder HD, Stiedl O, Smit AB, Spijker S

Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear.

Nat Neurosci. 2011 Oct;14(10):1302-8. PubMed: 21909089

PAPER Carew JD, Nair G, Andersen PM, Wuu J, Gronka S, Hu X, Benatar M

Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS.

Neurology. 2011 Oct 4;77(14):1370-5. PubMed: 21940617

PAPER Pappatà S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A, De Michele G, Salvatore M, Barone P

Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism.

Neurology. 2011 Oct 4;77(14):1357-62. PubMed: 21940621