Barbara Elmer

Germany

PAPER MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly MJ, Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, Pennacchio LA, Stamatoyannopoulos JA, Sunyaev SR, Valle D, Voight BF, Winckler W, Gunter C

Guidelines for investigating causality of sequence variants in human disease.

Nature. 2014 Apr 24;508(7497):469-76. PubMed: 24759409

Jürgen Götz on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

COMMENT I enjoyed reading this paper. The study adds to the notion that a prime function of tau is that of a scaffolding protein, not only in the axon but also in the dendrite where tau interacts, as this study shows, also with filamentous actin. Interesting is t

Matthew Wynn

University of California San Francisco
San Francisco, United States

Erik Roberson on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

COMMENT This is a very interesting and elegant study that adds support for the idea that tau is normally present in dendrites and plays a physiological role in normal synaptic functioning. The movement of tau into spines with neuronal activity is demonstrated in

PAPER Frandemiche ML, De Seranno S, Rush T, Borel E, Elie A, Arnal I, Lanté F, Buisson A

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

J Neurosci. 2014 Apr 23;34(17):6084-97. PubMed: 24760868

PAPER

NIH focuses on the brain.

J Nucl Med. 2013 Dec;54(12):9N. PubMed: 24297742

PAPER Mohammadi D

INMiND: getting to the bottom of neuroinflammation.

Lancet Neurol. 2013 Dec;12(12):1135-6. PubMed: 24229613

PAPER Sharma M, Krüger R, Gasser T

From genome-wide association studies to next-generation sequencing: lessons from the past and planning for the future.

JAMA Neurol. 2014 Jan;71(1):5-6. PubMed: 24190229

PAPER Zahodne LB, Schofield PW, Farrell MT, Stern Y, Manly JJ

Bilingualism does not alter cognitive decline or dementia risk among Spanish-speaking immigrants.

Neuropsychology. 2014 Mar;28(2):238-46. Epub 2013 Nov 4 PubMed: 24188113

PAPER Welberg L

Neurodegenerative disorders: A PIR-fect storm.

Nat Rev Drug Discov. 2013 Nov;12(11):827. PubMed: 24172329

PAPER Dodel R

[Towards a vaccine against Alzheimer's?].

Drug Res (Stuttg). 2013 Nov;63 Suppl 1:S18-20. Epub 2013 Nov 15 PubMed: 24242033

PAPER Thomas AA, Hunt KW, Volgraf M, Watts RJ, Liu X, Vigers G, Smith D, Sammond D, Tang TP, Rhodes SP, Metcalf AT, Brown KD, Otten JN, Burkard M, Cox AA, Do MK, Dutcher D, Rana S, DeLisle RK, Regal K, Wright AD, Groneberg R, Scearce-Levie K, Siu M, Purkey HE, Lyssikatos JP, Gunawardana IW

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.

J Med Chem. 2014 Feb 13;57(3):878-902. Epub 2014 Jan 22 PubMed: 24397738

PAPER Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J

Soluble T cell immunoglobulin and mucin domain (TIM)-1 and-4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and-17 bind to phosphatidylserine.

Biochim Biophys Acta. 2014 Feb;1843(2):275-87. Epub 2013 Nov 25 PubMed: 24286866

PAPER Folgosa L, Zellner HB, El Shikh ME, Conrad DH

Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding.

J Immunol. 2013 Dec 15;191(12):5951-8. Epub 2013 Nov 13 PubMed: 24227779