David Harrison

Takeda Cambridge Ltd
Cambridge

Odete Cruz e Silva

Universidade de Aveiro
Aveiro, Portugal

PrP Sc and recPrP (6D11)

ANTIBODY monoclonal 6D11 laboratory 6D11<br />(R.J. Kascsak, Department of Neurology, New York University School of Medicine, New York, NY<br />Paper, <a href="http://www.jleukbio.org/cgi/content/full/81/6/1374" target="_new">

Peter Davies on Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model.

COMMENT The results described are surprising, and do not readily fit with the work from Mucke's group on fyn. It is also amazing how the loss of STEP corrects the behavioral impairment, without modifying the underlying pathology at all—at least at this early

G. William Rebeck on Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model.

COMMENT Zhang et al. have published a very interesting study showing that deletion of the striatal-enriched tyrosine phosphatase (STEP) gene protects the 3xTg animal model of Alzheimer disease. The interesting part of this study is that the protection is not at t

PAPER Laird AS, Van Hoecke A, De Muynck L, Timmers M, Van Den Bosch L, Van Damme P, Robberecht W

Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy.

PLoS One. 2010;5(10):e13368. PubMed: 20967127

PAPER Bekenstein U, Kadener S

What can Drosophila teach us about iron-accumulation neurodegenerative disorders?

J Neural Transm. 2011 Mar;118(3):389-96. PubMed: 20967472

PAPER Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M

Fate mapping analysis reveals that adult microglia derive from primitive macrophages.

Science. 2010 Nov 5;330(6005):841-5. PubMed: 20966214

PAPER Vergani F, Landi A, Pirillo D, Cilia R, Antonini A, Sganzerla EP

Surgical, medical, and hardware adverse events in a series of 141 patients undergoing subthalamic deep brain stimulation for Parkinson disease.

World Neurosurg. 2010 Apr;73(4):338-44. PubMed: 20849789

PAPER Zhivotovsky B, Orrenius S

Cell cycle and cell death in disease: past, present and future.

J Intern Med. 2010 Nov;268(5):395-409. PubMed: 20964732

PAPER Mastroberardino PG, Piacentini M

Type 2 transglutaminase in Huntington's disease: a double-edged sword with clinical potential.

J Intern Med. 2010 Nov;268(5):419-31. PubMed: 20964734

PAPER Shao JL, Wan XH, Chen Y, Bi C, Chen HM, Zhong Y, Heng XH, Qian JQ

H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways.

J Mol Neurosci. 2011 Mar;43(3):453-60. PubMed: 20967511

PAPER Liu G, Guo H, Guo C, Zhao S, Gong D, Zhao Y

Involvement of IRE1α signaling in the hippocampus in patients with mesial temporal lobe epilepsy.

Brain Res Bull. 2011 Jan 15;84(1):94-102. PubMed: 20965234

Small STEP in Mice—Dare We Say Leap for AD?

RESEARCH NEWS 2010-10-24 Research News Could the field be one step closer to a new potential therapy for Alzheimer disease? Possibly, if the target is striatal-enriched tyrosine phosphatase (STEP). Deletion of this gene restored cognition and repaired synapses in AD transgenic mi

PAPER Binolfi A, Rodriguez EE, Valensin D, D'Amelio N, Ippoliti E, Obal G, Duran R, Magistrato A, Pritsch O, Zweckstetter M, Valensin G, Carloni P, Quintanar L, Griesinger C, Fernández CO

Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.

Inorg Chem. 2010 Nov 15;49(22):10668-79. PubMed: 20964419