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Tau264

RESEARCH MODELS Summary The Tau264 transgenic model expresses low levels of wild-type human tau. This mouse does not develop neuropathology or behavioral deficits. The phenotype information described on this page refers to heterozygous animals. Transgene expression in ...

Director, Wisconsin Alzheimer's Institute

JOB 2014-12-19 Employer University of Wisconsin School of Medicine and Public Health Description The Wisconsin Alzheimer's Institute (WAI) was established in 1998 as a center within the University of Wisconsin School of Medicine and Public Health (UWSMPH). The ...

Live-Cell Studies Blame Arginine Peptides for C9ORF72’s Crimes

RESEARCH NEWS 2014-12-19 Research News A variety of abnormal RNAs and peptides result from repeats in the C9ORF72 gene, the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. Which of these funky molecules instigates the death of cortical and ...

Iryna Benilova on Meet Sigma2, a New Aβ Receptor?

COMMENT Neurons contain multiple Aβ binding sites, from membrane receptors to gangliosides. It is currently unclear whether Aβ toxicity is mediated by ligand-receptor interactions or a less-specific mechanism. Using a phenotypic assay for membrane trafficking, ...

Meet Sigma2, a New Aβ Receptor?

CONFERENCE COVERAGE 2014-12-19 Conference Coverage Prion protein, insulin receptors, immunoglobulin-like receptors, PirB, unspecified membrane phospholipids, the list goes on … Now, add another purported Aβ receptor. At the Society for Neuroscience annual meeting in Washington, D.C., ...

Just for Her? Study of Women’s Biology Offers New Therapeutic Angle

CONFERENCE COVERAGE 2014-12-19 Conference Coverage It’s not news that women run a higher risk of Alzheimer’s disease than men. Nor is the thought that this has something to do with female sex hormones ebbing after menopause. Alas, hormone replacement has not worked, and it’s time for ...

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