PAPER Chae JS, Gil Hwang S, Lim DS, Choi EJ
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Tiina Kauppinen
University of ManitobaWinnipeg, Canada
Daniel Michaelson on Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice.
COMMENT Since the introduction of a novel approach, such as the use of the RXR agonist bexarotene to counteract AD pathology, often brings controversy, it is important to identify consensus observations that ensue. A key finding from the Landreth group (Cramer et
Michel Goedert on Distinct α-synuclein strains differentially promote tau inclusions in neurons.
COMMENT This work demonstrates the existence of assembled α-synuclein strains, based on the cross-seeding (or not) of tau aggregation. This is important for understanding some human neurodegenerative diseases, where α-synuclein inclusions are present in different
Kinase Mediates Mouse Motor Neuron Disease
RESEARCH NEWS 2013-07-10 Research News Scientist have long known that mutations in superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis, and now a paper in the July 1 Proceedings of the National Academy of Sciences suggests one possible reason why. Researchers from K
PAPER Amunts K, Lepage C, Borgeat L, Mohlberg H, Dickscheid T, Rousseau MÉ, Bludau S, Bazin PL, Lewis LB, Oros-Peusquens AM, Shah NJ, Lippert T, Zilles K, Evans AC
BigBrain: an ultrahigh-resolution 3D human brain model.
Science. 2013 Jun 21;340(6139):1472-5. PubMed: 23788795PAPER Strong MK, Southwell AL, Yonan JM, Hayden MR, Macgregor GR, Thompson LM, Steward O
Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background.
J Huntingtons Dis. 2012;1(2):221-241. PubMed: 23833693PAPER Lee CY, Cantle JP, Yang XW
Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.
FEBS J. 2013 Sep;280(18):4382-94. PubMed: 23829302PAPER Loane C, Wu K, Bain P, Brooks DJ, Piccini P, Politis M
Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD.
Neurology. 2013 May 14;80(20):1850-5. PubMed: 23596065PAPER Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N
Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis.
FEBS Lett. 2013 Aug 19;587(16):2500-5. PubMed: 23831581PAPER Emelyanov A, Andoskin P, Yakimovskii A, Usenko T, Nuzhnyi E, Nikolaev M, Pchelina S
SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia.
Parkinsonism Relat Disord. 2013 Jul 3; PubMed: 23830801PAPER Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR
Association between PARK16 and Parkinson's disease in the Han Chinese population: a meta-analysis.
Neurobiol Aging. 2013 Oct;34(10):2442.e5-9. PubMed: 23747047PAPER Marklund N, Farrokhnia N, Hånell A, Vanmechelen E, Enblad P, Zetterberg H, Blennow K, Hillered L
Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury.
J Neurotrauma. 2013 Jul 7; PubMed: 23829439PAPER Vardy ER, Ford AH, Gallagher P, Watson R, McKeith IG, Blamire A, O'Brien JT
Distinct cognitive phenotypes in Alzheimer's disease in older people.
Int Psychogeriatr. 2013 Oct;25(10):1659-66. PubMed: 23830521PAPER Norton MC, Clark C, Fauth EB, Piercy KW, Pfister R, Green RC, Corcoran CD, Rabins PV, Lyketsos CG, Tschanz JT
Caregiver personality predicts rate of cognitive decline in a community sample of persons with Alzheimer's disease. The Cache County Dementia Progression Study.
Int Psychogeriatr. 2013 Oct;25(10):1629-37. PubMed: 23830578Current Filters
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