Paul Aisen on A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease.

COMMENT It is quite interesting that stimulation of the fornix/hypothalamus influences memory, with notable effects on FDG-PET activity in the regions of abnormality in AD. With the success of DBS for Parkinson's, this approach is clearly feasible. Of course

PAPER Colin J, El Kebir S, Eydoux E, Hoang-Xuan T, Rozot P, Weiser M

Assessment of patient satisfaction with outcomes of and ophthalmic care for cataract surgery.

J Cataract Refract Surg. 2010 Aug;36(8):1373-9. PubMed: 20656162

Paul Saftig

University Kiel
Kiel, Germany

Amyloid β42 (G2-11)

ANTIBODY monoclonal G2-11 laboratory G2-11<br /><a href="http://www.biomedexperts.com/Profile.bme/115678/Konrad_Beyreuther" target="_new">Konrad Beyreuther</a><br />Center for Molecular Biology Heidelberg (ZMBH), Univers

Olga Meulenbroek

Netherlands

DBS Update: Attempting to Stimulate Memory in Alzheimer’s

RESEARCH NEWS 2010-08-11 Research News Researchers are sliding electrodes into the brains of people with Alzheimer disease, hoping to awaken memories and stave off disease-induced forgetfulness. In the August 4 Annals of Neurology online, a team led by Andres Lozano at Toronto We

Honolulu: Monkey, Rat Join Menagerie of Mammalian AD Models

CONFERENCE COVERAGE 2010-08-11 Conference Coverage Beyond the tried-and-true, though woefully imperfect lab mouse, Alzheimer disease researchers may have access to a growing repertoire of brainier, brawnier species for their in vivo studies. In particular, vervet and rat models strutte

PAPER Wu IC, Ohsawa I, Fuku N, Tanaka M

Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function.

Ann N Y Acad Sci. 2010 Jul;1201:111-20. PubMed: 20649547

PAPER Klin Y, Zlotnik A, Boyko M, Ohayon S, Shapira Y, Teichberg VI

Distribution of radiolabeled l-glutamate and d-aspartate from blood into peripheral tissues in naive rats: significance for brain neuroprotection.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):694-8. PubMed: 20691657

PAPER Gardner A, Boles RG

Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):730-43. PubMed: 20691744

PAPER Macedo B, Magalhães J, Batista AR, Saraiva MJ

Carvedilol treatment reduces transthyretin deposition in a familial amyloidotic polyneuropathy mouse model.

Pharmacol Res. 2010 Dec;62(6):514-22. PubMed: 20692343

PAPER Chen H, Chan DC

Physiological functions of mitochondrial fusion.

Ann N Y Acad Sci. 2010 Jul;1201:21-5. PubMed: 20649534

PAPER Brus M, Meurisse M, Franceschini I, Keller M, Lévy F

Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young.

Horm Behav. 2010 Nov;58(5):737-46. PubMed: 20692260

PAPER Serra M, Guaraldi M, Shea TB

Inhibitory neurons modulate spontaneous signaling in cultured cortical neurons: density-dependent regulation of excitatory neuronal signaling.

Phys Biol. 2010;7(2):026009. PubMed: 20526031

PAPER Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

J Biol Chem. 2010 Oct 1;285(40):30598-605. PubMed: 20693289