PAPER Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, Laferla FM, Kiyohara Y, Nakabeppu Y
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PAPER Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Wood A, Pangalos MN, Reinhart PH, Chin J
Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.
J Neurosci. 2013 Apr 17;33(16):7020-6. PubMed: 23595759PAPER Liu B, Frost JL, Sun J, Fu H, Grimes S, Blackburn P, Lemere CA
MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.
J Neurosci. 2013 Apr 17;33(16):7027-37. PubMed: 23595760PAPER Galimberti D, Scarpini E
Progress in Alzheimer's disease research in the last year.
J Neurol. 2013 Jul;260(7):1936-41. PubMed: 23595792PAPER Goo JS, Kim YB, Shim SB, Jee SW, Lee SH, Kim JE, Hwang IS, Lee YJ, Kwak MH, Lim CJ, Hong JT, Hwang DY
Nicastrin Overexpression in Transgenic Mice Induces Aberrant Behavior and APP Processing.
Mol Neurobiol. 2013 Apr 18; PubMed: 23595812PAPER Qiu C, von Strauss E, Bäckman L, Winblad B, Fratiglioni L
Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden.
Neurology. 2013 May 14;80(20):1888-94. PubMed: 23596063PAPER
Exercise slows decline in adults with Alzheimer's disease.
Front Aging Neurosci. 2013;5:17. PubMed: 23596226PAPER Diniz BS, Machado-Vieira R, Forlenza OV
Lithium and neuroprotection: translational evidence and implications for the treatment of neuropsychiatric disorders.
Neuropsychiatr Dis Treat. 2013;9:493-500. PubMed: 23596350PAPER Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S
Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.
J Neurosci. 2013 Apr 17;33(16):7099-107. PubMed: 23595767PAPER Harris JM, Gall C, Thompson JC, Richardson AM, Neary D, Du Plessis D, Pal P, Mann DM, Snowden JS, Jones M
Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia.
Neurology. 2013 May 14;80(20):1881-7. PubMed: 23596080PAPER Jellinger KA
Pathology and pathogenesis of vascular cognitive impairment-a critical update.
Front Aging Neurosci. 2013;5:17. PubMed: 23596414PAPER Geerts H, Roberts P, Spiros A, Carr R
A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease.
Front Pharmacol. 2013;4:47. PubMed: 23596419Rebecca M. Pruss on Stem Cell Screen Points to ALS Disease Target
COMMENT This is an exciting paper showing the ability to use a specific class of stem cell-derived neurons—motor neurons—to screen for potential neuroprotective small molecules. While the mouse ESC-derived neural cultures appear suitable for systematic screening,
Rebecca M. Pruss
TROPHOSMarseille, France
PAPER Rubin LL
Stem cells and drug discovery: the beginning of a new era?
Cell. 2008 Feb 22;132(4):549-52. PubMed: 18295572Current Filters
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