COMMENT The article represents a potentially interesting finding regarding the role of sTREM2 in triggering microglial activation. Although it is known that there is an increase in sTREM2 in many disease states, the role that sTREM2 plays is still relatively ...
COMMENT It was a pleasure to read this major and excellent paper that documents very elegantly the great potential of human PSCs for the development of better mouse models for AD. I did not expect the technique would be this powerful. This fascinating paper shows ...
RESEARCH NEWS 2017-02-25 Research News Mouse models of Alzheimer’s disease develop massive amyloidosis without losing many neurons, making them incomplete models of AD. In the February 23 Neuron, researchers led by Bart De Strooper and Pierre Vanderhaeghen at KU Leuven, Belgium, ...
COMMENT Zhong et al. report that soluble forms of TREM2 are able to elicit a robust proinflammatory response and promote survival in primary microglia. These findings provide a completely novel take on the biological roles of soluble TREM2. Previous work has ...
Washington University School of MedicineSaint Louis, United States
PAPER Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Eynden EV, Radaelli E, Tesseur I, Wray S, Ebneth A, Hardy J, Leroy K, Brion JP, Vanderhaeghen P, De Strooper B
PAPER Brion JP, Couck AM, Bruce M, Anderton B, Flament-Durand J1901750
PAPER Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B, McKenna S, Mobraaten L, Rajan TV, Greiner DL7995938
COMMENT This study by Ling et al. increases the number of football (soccer) cases in the literature with some element of CTE pathology. Although the numbers still remain small, the authors indicate that four of six cases with CTE pathology is a much higher ...
PAPER Bouchon A, Facchetti F, Weigand MA, Colonna M11323674
PAPER Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H
Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.J Biol Chem. 2005 Sep 23;280(38):32905-13. Epub 2005 Jul 26 PubMed: 16046394
Carol Dobson-Stone, John Kwok on Dreaded Anticipation: ALS Strikes Earlier in Successive Generations
COMMENT Genetic anticipation and the C9ORF72 repeat expansion Genetic anticipation is a phenomenon whereby the clinical symptoms of a genetic disorder become apparent at an earlier age as the disease is inherited from one generation to the next (Boonstra et al., ...
PAPER Ridley RM, Frith CD, Crow TJ, Conneally PM
Anticipation in Huntington's disease is inherited through the male line but may originate in the female.J Med Genet. 1988 Sep;25(9):589-95. PubMed: 2972838
PAPER Boonstra PS, Gruber SB, Raymond VM, Huang SC, Timshel S, Nilbert M, Mukherjee B
A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome.Genet Epidemiol. 2010 Nov;34(7):756-68. PubMed: 20878717
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