PAPER Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M
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Steven Brenner on Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain.
COMMENT This is potentially a good Alzheimer's model. There may be a number of different toxins or chemicals that contribute to development of Alzheimer's disease. D-galactose is also important as an aging model, and together, aluminum and D-galactose c
Suzanne Guenette on Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
COMMENT This paper shows that human embryonic stem (hES) cells overexpressing amyloid precursor protein (APP) display a robust differentiation towards a neural fate. APP-overexpressing H9 and HUES7 hES cells behaved similarly. Soluble APP fragments (sAPP) were sh
Sanjay Pimplikar on Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses.
COMMENT The remarkable, if not entirely surprising, findings reported in this paper should be of interest to the readers of Alzforum because of the current excitement in the field about "AD biomarkers." As summarized above, the study by Ioannidis and Pa
PAPER Kraft P
Curses--winner's and otherwise--in genetic epidemiology.
Epidemiology. 2008 Sep;19(5):649-51; discussion 657-8. PubMed: 18703928PAPER Ioannidis JP
Why most discovered true associations are inflated.
Epidemiology. 2008 Sep;19(5):640-8. PubMed: 18633328PAPER Ioannidis JP
Contradicted and initially stronger effects in highly cited clinical research.
JAMA. 2005 Jul 13;294(2):218-28. PubMed: 16014596PAPER Young NS, Ioannidis JP, Al-Ubaydli O
Why current publication practices may distort science.
PLoS Med. 2008 Oct 7;5(10):e201. PubMed: 18844432Amy Duffield on Risk factors and preventive interventions for Alzheimer disease: state of the science.
COMMENT Given the importance of magnesium (Mg) to brain function (Slutsky et al., 2010), it would seem to make sense to make sure older people are getting enough of this critical mineral. Mg plays an important role in protein kinases. Tyrosine-specific protein ki
PAPER Seelig MS
Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment.
Magnes Res. 1990 Sep;3(3):197-215. PubMed: 2132751Sonia George
Van Andel InstituteGrand Rapids, United States
PAPER Brun A, Gustafson L
The birth and early evolution of the frontotemporal dementia (FTD) concept.
J Mol Neurosci. 2011 Nov;45(3):324-9. PubMed: 21647707PAPER Bossù P, Salani F, Alberici A, Archetti S, Bellelli G, Galimberti D, Scarpini E, Spalletta G, Caltagirone C, Padovani A, Borroni B
Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients.
J Neuroinflammation. 2011;8:65. PubMed: 21645364PAPER Wang Z, Zhang Y, Zhang S, Guo Q, Tan Y, Wang X, Xiong R, Ding J, Chen S
DJ-1 can inhibit microtubule associated protein 1 B formed aggregates.
Mol Neurodegener. 2011;6:38. PubMed: 21645326PAPER Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
DJ-1 associates with synaptic membranes.
Neurobiol Dis. 2011 Sep;43(3):651-62. PubMed: 21645620Current Filters
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