RESEARCH NEWS 2016-08-31 Research News People who regularly flex their thinking muscles in old age may have an edge up on cognitive couch potatoes when it comes to protection against dementia. That is the main conclusion of a meta-analysis that investigated the effect of late ...
PAPER Lu Y, Tang C, Zhu L, Li J, Liang H, Zhang J, Xu R
The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.Int J Biol Sci. 2016;12(9):1140-9. Epub 2016 Aug 15 PubMed: 27570488
PAPER Marimuthu P, Varadarajan S, Krishnan M, Shanmugam S, Kunjuraman G, Ravinder JR, Arumugam B, Alex D, Swaminathan P
Evaluating the efficacy of memantine on improving cognitive functions in epileptic patients receiving anti-epileptic drugs: A double-blind placebo-controlled clinical trial (Phase IIIb pilot study).Ann Indian Acad Neurol. 2016 Jul-Sep;19(3):344-50. PubMed: 27570386
PAPER Gómez-Pinedo U, Galán L, Yañez M, Matias-Guiu J, Valencia C, Guerrero-Sola A, Lopez-Sosa F, Brin JR, Benito-Martin MS, Leon-Espinosa G, Vela-Souto A, Lendinez C, Guillamon-Vivancos T, Matias-Guiu JA, Arranz-Tagarro JA, Barcia JA, Garcia AG
Histological changes in the rat brain and spinal cord following prolonged intracerebroventricular infusion of cerebrospinal fluid from amyotrophic lateral sclerosis patients are similar to those caused by the disease.Neurologia. 2016 Aug 25; PubMed: 27570180
PAPER Melnikova T, Park D, Becker L, Lee D, Cho E, Sayyida N, Tian J, Bandeen-Roche K, Borchelt DR, Savonenko AV
Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease.Neurobiol Dis. 2016 Aug 25; PubMed: 27569580
PAPER Ganassi M, Mateju D, Bigi I, Mediani L, Poser I, Lee HO, Seguin SJ, Morelli FF, Vinet J, Leo G, Pansarasa O, Cereda C, Poletti A, Alberti S, Carra S
A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism.Mol Cell. 2016 Aug 25; PubMed: 27570075
PAPER Hosoi T, Kakimoto M, Tanaka K, Nomura J, Ozawa K27569458
PAPER Cavallo M, Signorino A, Perucchini ML
Benefits of Cognitive Treatments Administered to Patients Affected by Mild Cognitive Impairment/Mild Neurocognitive Disorder.Drug Dev Res. 2016 Aug 29; PubMed: 27569987
CONFERENCE COVERAGE 2016-08-30 Conference Coverage In the quest to find biomarkers that detect presymptomatic Alzheimer’s disease, some researchers are turning to measures of brain connectivity. Many studies have reported that functional circuits become disorganized early in the ...
PAPER Summerfield JJ, Hassabis D, Maguire EA18973817
PAPER Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL21653723
PAPER Tijms BM, Seriès P, Willshaw DJ, Lawrie SM21878484
COMMENT The paper by Wey et al. on PET imaging of HDACs appears to provide an important new proof of principle, showing that key epigenetic regulators can be imaged in human brain. There is growing evidence that class I HDACs play important roles in a highly ...
RESEARCH NEWS 2016-08-30 Research News Scientists are working out whether inhibitors of particular enzymes in one histone deacetylase (HDAC) family may one day restore normal transcription of genes in certain neurodegenerative disorders. Until now, though, they have been unable ...
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