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PAPER McManus ME, Ilett KF
Mixed function oxidase activity in a marsupial. The quokka (Seton;x brachyurus).
Drug Metab Dispos. 1976 May-Jun;4(3):199-202. PubMed: 6222Ajeet Rijal
Germany
Australia Report: Inflammation
CONFERENCE COVERAGE 2011-10-11 Conference Coverage The role of the immune system in Alzheimer’s disease (AD) remains poorly understood, in part because the tools are not at hand to distinguish myeloid-derived cells from microglia, the brain’s resident phagocytes. The field also needs b
Pam McClean on Modeling Sporadic PD in a Dish?
COMMENT I think this paper adds to the increasing literature on the consequences of extracellular α-synuclein and its role in PD pathogenesis. It represents an important validation of several recent studies showing that α-synuclein can be taken up by neurons from
Pam McClean
Massachusetts General Hospital/Harvard Medical SchoolCharlestown, United States
Sanjay Pimplikar on In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.
COMMENT In my view, the importance of this study lies in the finding that APP-induced neurodegeneration is cell autonomous. This study makes clever use of cell-specific promoters to show that only the APP-overexpressing cells undergo apoptosis while the neighbori
Chris Carter on Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
COMMENT ApoE doesn't just clear amyloid or carry cholesterol. A paper from Weintraub et al., 1987, showed that it is involved in dietary fat clearance, with very interesting differences between isoforms in the carriage of retinyl palmitate, a vitamin A precu
PAPER Weintraub MS, Eisenberg S, Breslow JL
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
J Clin Invest. 1987 Dec;80(6):1571-7. PubMed: 3479440PAPER Yrjänheikki J, Tikka T, Keinänen R, Goldsteins G, Chan PH, Koistinaho J
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13496-500. PubMed: 10557349PAPER Wang F, Wu H, Xu S, Guo X, Yang J, Shen X
Macrophage migration inhibitory factor activates cyclooxygenase 2-prostaglandin E(2) in cultured spinal microglia.
Neurosci Res. 2011 Nov;71(3):210-8. PubMed: 21802455PAPER Papadeas ST, Kraig SE, O'Banion C, Lepore AC, Maragakis NJ
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17803-8. PubMed: 21969586PAPER Rao MS, Mayer-Proschel M