PAPER Kitada T, Tomlinson JJ, Ao HS, Grimes DA, Schlossmacher MG
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PAPER Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JG, Kirkpatrick DS, Zhu H
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Sci Transl Med. 2012 Dec 12;4(164):164ra161. PubMed: 23241745PAPER Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ
ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
J Neurosci Methods. 2013 Mar 30;214(1):62-8. PubMed: 23318290PAPER Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, Sun L, Ma B, Ding J, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans JM, He P, Troncoso JC, Shen Y, Cai H
MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.
Hum Mol Genet. 2013 Feb 1;22(3):608-20. PubMed: 23125283PAPER Ramsden N, Perrin J, Ren Z, Lee BD, Zinn N, Dawson VL, Tam D, Bova M, Lang M, Drewes G, Bantscheff M, Bard F, Dawson TM, Hopf C
Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.
ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PubMed: 21812418PAPER Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
Hum Mol Genet. 2013 Mar 15;22(6):1140-56. PubMed: 23241358PAPER Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
J Neural Transm (Vienna). 2011 May;118(5):795-808. Epub 2011 May 7 PubMed: 21552986M. Flint Beal on Protein Destroying Muscle, Bone, Nerves Parks on Mitochondria
COMMENT The link between these two papers is that VCP mutations have deleterious effects on mitochondria. However, the two groups approach this from different directions. Plun-Favreau et al. studied mitochondrial function in fibroblasts and show that there is unc
PAPER Pomerantz BJ, Reznikov LL, Harken AH, Dinarello CA
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2871-6. PubMed: 11226333PAPER Gangemi S, Basile G, Merendino RA, Minciullo PL, Novick D, Rubinstein M, Dinarello CA, Lo Balbo C, Franceschi C, Basili S, D' Urbano E, DavĂ G, Nicita-Mauro V, Romano M
Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Exp Gerontol. 2003 Jun;38(6):669-72. PubMed: 12814802Gunnar Gouras on Like Star Born of Supernova, Plaque Born of Exploded Neuron?
COMMENT I'd like to clarify and extend my quoted comments about the interesting talk by Charlie Glabe at the AD/PD meeting. I was mainly referring to his new images of nuclear aggregates. Charlie did also show very nice new images of plaques appearing to ari
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Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.
Antimicrob Agents Chemother. 1979 Feb 1;15(2):240-42. PubMed: 34360PAPER Kjessler B, Farhan M
Delayed diagnosis in a case of secondary amenorrhea caused by a long arm isochromosome--X; i(xq).
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[Stomach cancer. 2. Evaluation of operability of the cancer].
Rev Infirm. 1975 Mar 1;25(3):207-12. PubMed: 47642Current Filters
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