Faulty DNA Repair Gene Leads to Cognitive Problems

RESEARCH NEWS 2011-09-09 Research News No question, a neuron’s DNA takes a beating throughout a person’s lifetime. Damage to neuronal DNA has been shown to accumulate with age and is also up in Alzheimer’s disease (AD) patients (see ARF related news story on Lu et al., 2004, and

EU Consortium Applies Nanotechnology to Study AD

RESEARCH NEWS 2011-09-09 Research News Most research into nanomedicine, the application of nanoscale materials and processes to medical problems, has focused on cancer. Now researchers are starting to see opportunities for these approaches in Alzheimer’s disease (AD). With its Se

AlzGene Reorg—"Top Results" Reduced to Elite Few

COMMUNITY NEWS 2011-09-09 Community News Astute readers may have noticed that the 40 or so genes once populating AlzGene’s Top Results list have been culled to 10, and that former hits such as SORL1 and GAB2 no longer make the current cut. What happened, and why? “We have changed

PAPER Kabadi SV, Stoica BA, Loane DJ, Byrnes KR, Hanscom M, Cabatbat RM, Tan MT, Faden AI

Cyclin D1 Gene Ablation Confers Neuroprotection in Traumatic Brain Injury.

J Neurotrauma. 2012 Jan 13; PubMed: 21895533

PAPER Green DR, Galluzzi L, Kroemer G

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging.

Science. 2011 Aug 26;333(6046):1109-12. PubMed: 21868666

PAPER Sippl C, Bosserhoff AK, Fischer D, Tamm ER

Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins.

Exp Eye Res. 2011 Nov;93(5):669-80. PubMed: 21896272

PAPER Wang J, Zhang Y, Tang L, Zhang N, Fan D

Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis.

Neurosci Lett. 2011 Oct 10;503(3):250-5. PubMed: 21896316

PAPER Brooks DJ, Pavese N

Imaging biomarkers in Parkinson's disease.

Prog Neurobiol. 2011 Dec;95(4):614-28. PubMed: 21896306

PAPER Li Y, Zhang L, Kallakuri S, Zhou R, Cavanaugh JM

Quantitative relationship between axonal injury and mechanical response in a rodent head impact acceleration model.

J Neurotrauma. 2011 Sep;28(9):1767-82. PubMed: 21895482

PAPER Funkiewiez A, Bertoux M, de Souza LC, Lévy R, Dubois B

The SEA (social cognition and emotional assessment): A clinical neuropsychological tool for early diagnosis of frontal variant of frontotemporal lobar degeneration.

Neuropsychology. 2011 Sep 5; PubMed: 21895376

PAPER Nygård L, Pantzar M, Uppgard B, Kottorp A

Detection of activity limitations in older adults with MCI or Alzheimer's disease through evaluation of perceived difficulty in use of everyday technology: A replication study.

Aging Ment Health. 2011 Sep 7; PubMed: 21895555

PAPER Krintel C, Frydenvang K, Olsen L, Kristensen MT, de Barrios O, Naur P, Francotte P, Pirotte B, Gajhede M, Kastrup JS

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

Biochem J. 2012 Jan 1;441(1):173-8. PubMed: 21895609

PAPER Yamaoka M, Osawa S, Morinaga T, Takenaka S, Yoshida K

A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease.

Microb Cell Fact. 2011;10:69. PubMed: 21896210

PAPER Derouesné C

[Speech and regulation of behavior: the works of LS Vygosty and AR Luria].

Geriatr Psychol Neuropsychiatr Vieil. 2011 Sep;9(3):355-62. PubMed: 21896438

PAPER Coudin G, Mollard J

[Difficulties, coping strategies and satisfactions in family caregivers of people with Alzheimer's disease].

Geriatr Psychol Neuropsychiatr Vieil. 2011 Sep;9(3):363-78. PubMed: 21896439