RESEARCH NEWS 2015-03-05 Research News Pathological proteins likely harm cognition by acting on synapses, but the details of how these proteins impair transmission largely remain a black box. In the March 4 Neuron, researchers led by Edward Stern at Bar-Ilan University in Ramat ...
Thomas Bayer, Oliver Wirths on Mistakes Prompt Retraction of Controversial Paper, and Publication Ban
COMMENT Whether intraneuronal Aβ peptides play a (key) role in the etiology of Alzheimer’s disease (AD) is still a matter of scientific debate. Since the initial publication in 2003, the 3xTg mouse model (Oddo et al., 2003) has attracted considerable attention ...
RESEARCH NEWS 2015-03-05 Research News On February 25, the Journal of Neuroscience quietly posted on its website its retraction of a 2011 paper that questioned the existence of Aβ aggregates inside neurons. In a terse statement, the journal, a publication of the Society for ...
Icahn School of Medicine at Mount SinaiNew York, United States
PAPER Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C
Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.Brain. 2015 Mar 1; PubMed: 25732182
CONFERENCE COVERAGE 2015-03-04 Conference Coverage Under healthy conditions, microglia look placid. They sit evenly spaced throughout the brain, processes extended, quietly doing their job of scanning for debris. When disease kicks in, these calm cells can transmogrify and end up doing ...
PAPER Daneman R, Zhou L, Kebede AA, Barres BA20944625
PAPER Schadt EE, Friend SH, Shaywitz DA19337271
PAPER Kotas ME, Medzhitov R25723161
PAPER Medzhitov R18650913
PAPER Seong SY, Matzinger P
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.Nat Rev Immunol. 2004 Jun;4(6):469-78. PubMed: 15173835
PAPER A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.Immunity. 2009 Aug 21;31(2):245-58. Epub 2009 Jul 30 PubMed: 19646905
No filters selected