RESEARCH MODELS This mouse model is a cross between a well-characterized APP transgenic (APP23) and a PSEN1 knock-in mouse (PS1-R278I) that expresses human PSEN1 with a mutation linked to atypical AD. The R278I mutation alters γ-secretase processing of APP leading to ...
MUTATIONS MAPT Exon 11 Point, Missense Coding Impaired tubulin polymerization. Altered tau aggregation in an isoform-specific manner; accelerated tau assembly in 4R tau while decreasing tau aggregation, misfolding, and filament assembly in 3R tau. Lobar atrophy, ...
Michael Coleman, Jonathan Gilley on Neurobiology. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
COMMENT Progress in science usually comes from considering two apparently contradictory findings and asking how both can be correct. On this occasion there are two such results. One is the striking data reported by Gerdts and colleagues indicating that artificial ...
PAPER Yahata N, Yuasa S, Araki T
Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.J Neurosci. 2009 May 13;29(19):6276-84. PubMed: 19439605
PAPER Shen H, Hyrc KL, Goldberg MP23892229
PAPER Gilley J, Orsomando G, Nascimento-Ferreira I, Coleman MP25818290
PAPER Gilley J, Coleman MP20126265
PAPER Gilley J, Adalbert R, Yu G, Coleman MP23946398
Merck Research LaboratoriesNorth Wales
CAMDTucson, United States
GRANT Monday, May 4, 2015- 12:30 National Institute of Neurological Disorders and Stroke The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Applications are accepted by continuous ...
T1 Translational Research: Novel Interventions for Prevention and Treatment of Age-related Conditions (R21)
GRANT Monday, May 4, 2015- 12:15 NIA intends to fund up to four to five awards for this & the companion T2 FOA, for a total of $1,000,000 for fiscal year 2016. Future year amounts will depend on annual appropriations. The combined budget for direct costs ...
T2 Translational Research: Research Leading to New Health Care Practices, Community Programs and Policies Affecting Older Persons (R21)
GRANT Monday, May 4, 2015- 12:15 National Institute on Aging NIA intends to fund up to four to five awards for this and the companion PAR-15-190, for a total of $1,000,000 for fiscal year 2015. Future year amounts will depend on annual appropriations. Multiple ...
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