RESEARCH MODELS Summary These mice were generated to determine how BACE overexpression affects the processing of APP in vivo. Two transgenic lines were reported (BACE54/4 and BACE54/11) both expressing human BACE at high levels in the brain. Human BACE mRNA was approxima
University of Rochester Medical CenterUnited States
RESEARCH MODELS Modification Details Human 4-repeat tau driven by the PDGF-β promoter. Tagged with myc and Flag on the N- and C-terminals respectively. Neuropathology SDS-insoluble tau aggregates in hippocampus. Degenerating neurons in the hippocampus containing phosphor
RESEARCH MODELS Modification Details Transgene containing human 4-repeat tau cDNA with the R406W mutation containing myc and FLAG tags at N-and C-terminal ends, respectively, and driven by the CaMK-II promoter. Neuropathology Argyrophilic and congophilic tau inclusions i
RESEARCH MODELS Summary Three lines of transgenic mice expressing different levels of human BACE were generated. Line 30 (BACE-L) expressed the lowest amount of BACE, followed by line 34 (BACE-M), and line 8 (BACE-H). These lines expressed human BACE at levels approximat
CONFERENCE COVERAGE 2013-11-27 Conference Coverage Slow enrollment often hobbles Alzheimer’s clinical trials. At a November 1–2 meeting at the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, stakeholders brainstormed ways to reach new participants and keep them engaged.
CONFERENCE COVERAGE 2013-11-27 Conference Coverage Pathology studies show that tau tangles, unlike amyloid, track closely with the cognitive decline of Alzheimer’s disease. This has raised hope that the tau PET tracers being developed will allow researchers to stage disease, and early
PAPER Hoffman P, Evans GA, Lambon Ralph MA
Cortex. 2014 Jan;50:19-31. Epub 2013 Oct 30 PubMed: 24268323
PAPER Eisen A, Turner MR, Lemon R
Muscle Nerve. 2014 Apr;49(4):469-77. Epub 2013 Dec 18 PubMed: 24273101
PAPER Dulovic M, Jovanovic M, Xilouri M, Stefanis L, Harhaji-Trajkovic L, Kravic-Stevovic T, Paunovic V, Ardah MT, El-Agnaf OM, Kostic V, Markovic I, Trajkovic V
Neurobiol Dis. 2014 Mar;63:1-11. Epub 2013 Nov 20 PubMed: 24269733
PAPER Bhatt MA, Messer A, Kordower JH
J Parkinsons Dis. 2013;3(4):581-91. PubMed: 24270241
PAPER Aureli C, Cassano T, Masci A, Francioso A, Martire S, Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d'Erme M, Mosca L
J Neurosci Res. 2014 Mar;92(3):347-58. Epub 2013 Nov 22 PubMed: 24273027
PAPER van den Bogaard SJ, Kruit MC, Dumas EM, Roos RA
J Neurol Sci. 2014 Jan 15;336(1-2):254-6. Epub 2013 Oct 9 PubMed: 24268924