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Jie Shen on Pathogenic Presenilin Mutations Generate Aβ43

COMMENT I would like to start my comment by stating the obvious—science is about finding the truth, and ultimately the truth prevails. Since our response paper published in Neuron has already thoroughly addressed the issues, including the technical limitations ...

Nikki Bowen


Primary Care Associates
Williamston, United States

Reining in APP’s Early Moves Could Curb Aβ

RESEARCH NEWS 2016-04-29 Research News Intracellular trafficking of the amyloid precursor protein (APP) is thought to go awry in Alzheimer’s disease, but most studies focus on later stages of the process, when this membrane protein recycles through endosomes. Could earlier phases ...

Pathogenic Presenilin Mutations Generate Aβ43

RESEARCH NEWS 2016-04-29 Research News Papers in the March 17 EMBO Molecular Medicine and the April 20 Neuron have reignited a simmering debate about the role of presenilin mutations in familial Alzheimer’s disease. Both studies dispute a claim made previously by Jie Shen, Ray ...

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