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At Least We Know These Don’t Work: Negative Trials at CTAD

CONFERENCE COVERAGE 2017-12-15 Conference Coverage Confirming once again that not only anti-amyloid therapeutic approaches struggle to score a win in Alzheimer’s and related dementias, the 10th CTAD conference, held November 1–4 in Boston, featured rest-in-peace presentations on a ...

Maurice Marr


Financial Economics Association
Georgetown, United States

Suzee Lee on Before 40, Brain Atrophy in ALS Mutation Carriers?

COMMENT This large cohort of presymptomatic C9ORF72 expansion carriers shows a surprising and interesting new finding of lower praxis scores. Future longitudinal studies will be needed to determine whether the early gray-matter and white-matter deficits also seen ...

PAPER Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Troakes C, Al-Sarraj S, Lashley R, Holton J, Compta Y, Van Deerlin V, Serrano GE, Beach TG, Lesage S, Galasko D, Masliah E, Santana I, Pastor P, Diez-Fairen M, Aguilar M, Tienari PJ, Myllykangas L, Oinas M, Revesz R, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Pickering-Brown S, Mann D, Halliday GM, Hardy J, Trojanowski JQ, Dickson DW, Singleton A, Stone DJ, Bras J

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

The Lancet Neurol, Dec 15, 2107.

In the Running: Trial Results from CTAD Conference

CONFERENCE COVERAGE 2017-12-15 Conference Coverage Researchers presented a fall crop of Phase 1 results at the recent Clinical Trials in Alzheimer’s Disease meeting, held November 1–4 in Boston. New treatments aimed at neurotrophin signaling, tau, and cholinergic pathways moved on to ...

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