PAPER Clos AL, Kayed R, Lasagna-Reeves CA
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329930 RESULTS
PAPER Imanishi T, Hossain MM, Suzuki T, Xu P, Sato I, Kobayashi H
Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats.
Adv Pharmacol Sci. 2012;2012:708178. PubMed: 22319525PAPER Lee JY, Cho E, Seo JW, Hwang JJ, Koh JY
Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.
J Neuropathol Exp Neurol. 2012 Mar;71(3):211-22. PubMed: 22318122PAPER Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X
The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.
J Neuropathol Exp Neurol. 2012 Mar;71(3):233-41. PubMed: 22318126PAPER Miklós I, Zádori Z
Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.
PLoS Comput Biol. 2012 Feb;8(2):e1002356. PubMed: 22319430Dennis Selkoe on α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
COMMENT Since our publication (Bartels et al., 2011), we have conducted extensive experiments using both Clear Native (CN) PAGE and in-vivo crosslinking of endogenous cellular α-synuclein. Regarding the former method, the migration of endogenous human α-synuclein
Leon Tai on Upping Brain ApoE, Drug Treats Alzheimer's Mice
COMMENT The issue of whether to increase or decrease ApoE levels for AD therapy is confounded by the multiple functions of ApoE. In a landmark paper, Landreth and coworkers clearly demonstrate that bexarotene treatment, an RXR agonist, increases endogenous mouse
Eric Luth
Brigham and Women’s Hospital/Harvard Medical SchoolUnited States
Ulf Dettmer
Harvard Medical School, Brigham and Women’s HospitalUnited States
PAPER Black SE
Brain stimulation, learning, and memory.
N Engl J Med. 2012 Feb 9;366(6):563-5. PubMed: 22316451PAPER Suthana N, Haneef Z, Stern J, Mukamel R, Behnke E, Knowlton B, Fried I
Memory enhancement and deep-brain stimulation of the entorhinal area.
N Engl J Med. 2012 Feb 9;366(6):502-10. PubMed: 22316444Vincent Marchesi on Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.
COMMENT This paper deals with the question of whether small blood vessel damage is a primary factor in the pathogenesis of AD, an idea advanced years ago that has since been eclipsed by the deluge of experimental data that incriminates amyloid aggregates as the m