PAPER Stubendorff K, Hansson O, Minthon L, Londos E

Differences in survival between patients with dementia with Lewy bodies and patients with Alzheimer's disease--measured from a fixed cognitive level.

Dement Geriatr Cogn Disord. 2011;32(6):408-16. PubMed: 22327504

PAPER Braidy N, Jayasena T, Poljak A, Sachdev PS

Sirtuins in cognitive ageing and Alzheimer's disease.

Curr Opin Psychiatry. 2012 May;25(3):226-30. PubMed: 22327552

PAPER Dries DR, Yu G, Herz J

Extracting β-amyloid from Alzheimer's disease.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3199-200. PubMed: 22328154

PAPER Corbett A, Smith J, Creese B, Ballard C

Treatment of behavioral and psychological symptoms of Alzheimer's disease.

Curr Treat Options Neurol. 2012 Apr;14(2):113-25. PubMed: 22328204

PAPER Adams MK, Simpson JA, Richardson AJ, English DR, Aung KZ, Makeyeva GA, Guymer RH, Giles GG, Hopper J, Robman LD, Baird PN

Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study.

Am J Epidemiol. 2012 Mar 15;175(6):511-8. PubMed: 22328704

PAPER Song M, Xiong JX, Wang YY, Tang J, Zhang B, Bai Y

VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice.

PLoS One. 2012;7(2):e29790. PubMed: 22328918

PAPER Mattsson N, Rajendran L, Zetterberg H, Gustavsson M, Andreasson U, Olsson M, Brinkmalm G, Lundkvist J, Jacobson LH, Perrot L, Neumann U, Borghys H, Mercken M, Dhuyvetter D, Jeppsson F, Blennow K, Portelius E

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system.

PLoS One. 2012;7(2):e31084. PubMed: 22328928

PAPER Rossello XS, Igbavboa U, Weisman GA, Sun GY, Wood WG

AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes.

Brain Res. 2012 Mar 20;1444:87-95. PubMed: 22325097

PAPER Kou J, Song M, Pattanayak A, Lim JE, Yang J, Cao D, Li L, Fukuchi K

Combined treatment of Aβ immunization with statin in a mouse model of Alzheimer's disease.

J Neuroimmunol. 2012 Mar;244(1-2):70-83. PubMed: 22326143

PAPER Zampagni M, Wright D, Cascella R, D'Adamio G, Casamenti F, Evangelisti E, Cardona F, Goti A, Nacmias B, Sorbi S, Liguri G, Cecchi C

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models.

Free Radic Biol Med. 2012 Apr 15;52(8):1362-71. PubMed: 22326489

PAPER Hashimoto M, Aoki M, Winblad B, Tjernberg LO

A novel approach for Aβ₁₋₄₀ quantification using immuno-PCR.

J Neurosci Methods. 2012 Apr 15;205(2):364-7. PubMed: 22327103

Suzanne Guenette on Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.

COMMENT This is an excellent study. Not only is the novel interaction of APP/APLP C-terminal fragments with GαS shown to trigger neurite outgrowth, but also the involvement of cAMP/PKA activation and GSK-3β inhibition is in agreement with published evidence showi

Andres M. Lozano on Memory enhancement and deep-brain stimulation of the entorhinal area.

COMMENT The work from the group at UCLA is exciting and could have important implications for patients with memory disturbances. Just as deep-brain stimulation has been used to modify the activity of brain areas involved in movement in over 80,000 patients with P

Andres M. Lozano

Toronto Western Hospital
Toronto, Canada

Adam Kline on Upping Brain ApoE, Drug Treats Alzheimer's Mice

COMMENT Some LXR ligands interact directly with γ-secretase. The structure of bexarotene suggests that it, too, may have a direct interaction with the complex. Given the rapidity of the effects observed, it would be interesting to see data for this compound in a