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APP-C99 (tg13592)

RESEARCH MODELS Modification Details Transgene consisting of the signal plus 99-amino acid carboxyl-terminal sequence (SbC) of human APP under the control of a cytomegalovirus enhancer/β-actin promoter. Neuropathology Although the transgene is expressed in brain and skel

Rotman Research Institute 2014 Annual Neuroscience Conference

CONFERENCE 2014-03-10 00:00:00-2014-03-11 00:00:00 Omni King Edward Hotel, Toronto, Canada 10 March 2014 to 11 March 2014 Join world-renowned scientists in Toronto at the 24th annual Baycrest Rotman Research Institute conference titled "Memory and the Brain in Health and Disease." March 10-11, 2

Diagnosis

Other Important Notice:  The Alzheimer Research Forum does not provide medical advice. The contents are for informational purposes only and are not intended to substitute for professional medical advice, diagnosis or treatment. Always seek advice from a qualifi

Tg-mAPP/RAGE

RESEARCH MODELS Neuropathology Significantly increased activation of microglia and astrocytes compared to mice expressing mutant APP alone. Cognition/Behavior Tg-mAPP/RAGE mice display abnormalities in spatial learning and memory at age three to four months of age, where

Q&A with Richard Bozanich

Other Questions by Gabrielle Strobel Richard Bozanich, 50, has early onset dementia, Probable Alzheimer's Type. During his career, Bozanich was a journalist who wrote and/or edited for the Harvard Business School, the Los Angeles Times, the Dallas Morning

Interview: One Man's Forward Approach

Other Thomas Greene's mother developed AD in her mid-thirties. Thomas decided to end uncertainty about his own genetic status and took a predictive test when he was 31. When it came back positive for an AD mutation, he grabbed the bull by its horns as best

Interview with Jennifer Williamson

Other By Gabrielle Strobel Jennifer Williamson is a genetic counselor at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center at Columbia University, New York. She sees families with neurogenetic

Tg-mAPP/DN-RAGE

RESEARCH MODELS Neuropathology Bigenic mice expressing dominant-negative RAGE as well as mutant APP displayed diminished neuropathology compared with mice expressing mutant APP alone, including the area occupied by acetylcholinesterase-positive fibers in the subiculum at

NPR Audio Interviews with Thomas Debaggio

Other When he was 55, herb farmer Tom DeBaggio, called the "Best Rosemaryologist in the country," began to notice problems with his memory. Working the checkout register of his family business, he could not name plants he'd been growing for decad

Where to Turn for Research: Human Studies of eFAD

Other By Gabrielle Strobel Editor's note:  For definitions of early onset Alzheimer disease (EOAD) and early onset familial Alzheimer disease (eFAD), please see our essay, What Is Early Onset Familial Alzheimer Disease (eFAD)? Families with eFAD who are wi

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