Luciano D'Adamio on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT I agree with the comments underlying the importance of this paper, which supports the pathogenic role of APP processing by BACE in sporadic AD. As noted in many comments, these findings also suggest that inhibition of BACE processing of APP will be a bene

Nahuai Badiola

Institute for Research in Biomedicine
Barcelona, Spain

Experimental α7 Agonist Meets Cognitive and Clinical Endpoints

CONFERENCE COVERAGE 2012-07-18 Conference Coverage In Alzheimer’s disease drug development, how often does it happen that a large phase 2b trial of an experimental medicine cleanly meets both primary and secondary endpoints as set out in the protocol? Today, at the Alzheimer’s Associat

PAPER Premi E, Garibotto V, Alberici A, Paghera B, Giubbini R, Padovani A, Borroni B

Nature versus Nurture in Frontotemporal Lobar Degeneration: the Interaction of Genetic Background and Education on Brain Damage.

Dement Geriatr Cogn Disord. 2012;33(6):372-8. PubMed: 22797130

PAPER Knight LS, Wenzel HJ, Schwartzkroin PA

Inhibition and interneuron distribution in the dentate gyrus of p35 knockout mice.

Epilepsia. 2012 Jun;53 Suppl 1:161-70. PubMed: 22612821

PAPER Yang M, Kim JS, Kim J, Jang S, Kim SH, Kim JC, Shin T, Wang H, Moon C

Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer.

Brain Res Bull. 2012 Oct 1;89(1-2):50-6. PubMed: 22796103

PAPER Constant JP, Fraley GS, Forbes E, Hallas BH, Leheste JR, Torres G

Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation.

Neuroscience. 2012 Oct 11;222:333-42. PubMed: 22796077

PAPER Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy.

Neurodegener Dis. 2012 Jul 10; PubMed: 22796753

PAPER Lang L, Kurnik M, Danielsson J, Oliveberg M

Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium.

Proc Natl Acad Sci U S A. 2012 Jul 13; PubMed: 22797895

PAPER Yin F, Boveris A, Cadenas E

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration.

Antioxid Redox Signal. 2012 Sep 5; PubMed: 22793257

PAPER Castaño Guerrero Y, González Fraguela ME, Fernández Verdecia I, Horruitiner Gutiérrez I, Piedras Carpio S

Changes in oxidative metabolism and memory and learning in an cerebral hypoperfusion model in rats.

Neurologia. 2012 Jul 11; PubMed: 22795923

PAPER Chen Y, Zeng Y, Huang R, Yang Y, Chen K, Song W, Zhao B, Li J, Yuan L, Shang HF

No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population.

Neurobiol Aging. 2012 Nov;33(11):2721.e3-5. PubMed: 22795786

PAPER Kong M, Ba M, Liang H, Ma L, Yu Q, Yu T, Wang Y

5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell.

Neurosci Lett. 2012 Aug 22;524(1):35-9. PubMed: 22796470

PAPER Permpoonputtana K, Mukda S, Govitrapong P

Effect of melatonin on D-amphetamine-induced neuroglial alterations in postnatal rat hippocampus and prefrontal cortex.

Neurosci Lett. 2012 Aug 22;524(1):1-4. PubMed: 22796652

PAPER Peters HL, Tuli A, Wang X, Liu C, Pan Z, Ouellette MM, Hollingsworth MA, MacDonald RG, Solheim JC

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.

Int J Oncol. 2012 Jul 13; PubMed: 22797723